Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus offering a potential therapeutic strategy.

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Autores principales:	Noriyuki Kishi, Jessica L. MacDonald, Julia Ye, Bradley J. Molyneaux, Eiman Azim, Jeffrey D. Macklis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/573f6b6aaf6a4976a621f82c8007141a
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spelling	oai:doaj.org-article:573f6b6aaf6a4976a621f82c8007141a2021-12-02T16:57:01ZReduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice10.1038/ncomms105202041-1723https://doaj.org/article/573f6b6aaf6a4976a621f82c8007141a2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10520https://doaj.org/toc/2041-1723Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus offering a potential therapeutic strategy.Noriyuki KishiJessica L. MacDonaldJulia YeBradley J. MolyneauxEiman AzimJeffrey D. MacklisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noriyuki Kishi Jessica L. MacDonald Julia Ye Bradley J. Molyneaux Eiman Azim Jeffrey D. Macklis Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
description	Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus offering a potential therapeutic strategy.
format	article
author	Noriyuki Kishi Jessica L. MacDonald Julia Ye Bradley J. Molyneaux Eiman Azim Jeffrey D. Macklis
author_facet	Noriyuki Kishi Jessica L. MacDonald Julia Ye Bradley J. Molyneaux Eiman Azim Jeffrey D. Macklis
author_sort	Noriyuki Kishi
title	Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
title_short	Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
title_full	Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
title_fullStr	Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
title_full_unstemmed	Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
title_sort	reduction of aberrant nf-κb signalling ameliorates rett syndrome phenotypes in mecp2-null mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/573f6b6aaf6a4976a621f82c8007141a
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Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

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