Role of the hippocampal CA1 region in incremental value learning

Abstract It is generally believed that the hippocampus plays a crucial role in declarative memory—remembering facts and events—but not in gradual stimulus-response association or incremental value learning. Based on the finding that CA1 conveys strong value signals during dynamic foraging, we invest...

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Autores principales:	Yeongseok Jeong, Namjung Huh, Joonyeup Lee, Injae Yun, Jong Won Lee, Inah Lee, Min Whan Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57412bb9e8ef4a70a7dbe27b0a763eeb
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spelling	oai:doaj.org-article:57412bb9e8ef4a70a7dbe27b0a763eeb2021-12-02T15:08:10ZRole of the hippocampal CA1 region in incremental value learning10.1038/s41598-018-28176-52045-2322https://doaj.org/article/57412bb9e8ef4a70a7dbe27b0a763eeb2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28176-5https://doaj.org/toc/2045-2322Abstract It is generally believed that the hippocampus plays a crucial role in declarative memory—remembering facts and events—but not in gradual stimulus-response association or incremental value learning. Based on the finding that CA1 conveys strong value signals during dynamic foraging, we investigated the possibility that the hippocampus contributes to incremental value learning. Specifically, we examined effects of inactivating different subregions of the dorsal hippocampus on behavioral performance of mice performing a dynamic foraging task in a modified T-maze. A reinforcement learning model-based analysis indicated that inactivation of CA1, but not dentate gyrus, CA3, or CA2, impaired trial-by-trial updating of chosen value without affecting value-dependent action selection. As a result, it took longer for CA1-inactivated mice to bias their choices toward the higher-reward-probability target after changes in reward probability. Our results indicate, contrary to the traditional view, that the hippocampus, especially CA1, might contribute to incremental value learning under certain circumstances.Yeongseok JeongNamjung HuhJoonyeup LeeInjae YunJong Won LeeInah LeeMin Whan JungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yeongseok Jeong Namjung Huh Joonyeup Lee Injae Yun Jong Won Lee Inah Lee Min Whan Jung Role of the hippocampal CA1 region in incremental value learning
description	Abstract It is generally believed that the hippocampus plays a crucial role in declarative memory—remembering facts and events—but not in gradual stimulus-response association or incremental value learning. Based on the finding that CA1 conveys strong value signals during dynamic foraging, we investigated the possibility that the hippocampus contributes to incremental value learning. Specifically, we examined effects of inactivating different subregions of the dorsal hippocampus on behavioral performance of mice performing a dynamic foraging task in a modified T-maze. A reinforcement learning model-based analysis indicated that inactivation of CA1, but not dentate gyrus, CA3, or CA2, impaired trial-by-trial updating of chosen value without affecting value-dependent action selection. As a result, it took longer for CA1-inactivated mice to bias their choices toward the higher-reward-probability target after changes in reward probability. Our results indicate, contrary to the traditional view, that the hippocampus, especially CA1, might contribute to incremental value learning under certain circumstances.
format	article
author	Yeongseok Jeong Namjung Huh Joonyeup Lee Injae Yun Jong Won Lee Inah Lee Min Whan Jung
author_facet	Yeongseok Jeong Namjung Huh Joonyeup Lee Injae Yun Jong Won Lee Inah Lee Min Whan Jung
author_sort	Yeongseok Jeong
title	Role of the hippocampal CA1 region in incremental value learning
title_short	Role of the hippocampal CA1 region in incremental value learning
title_full	Role of the hippocampal CA1 region in incremental value learning
title_fullStr	Role of the hippocampal CA1 region in incremental value learning
title_full_unstemmed	Role of the hippocampal CA1 region in incremental value learning
title_sort	role of the hippocampal ca1 region in incremental value learning
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/57412bb9e8ef4a70a7dbe27b0a763eeb
work_keys_str_mv	AT yeongseokjeong roleofthehippocampalca1regioninincrementalvaluelearning AT namjunghuh roleofthehippocampalca1regioninincrementalvaluelearning AT joonyeuplee roleofthehippocampalca1regioninincrementalvaluelearning AT injaeyun roleofthehippocampalca1regioninincrementalvaluelearning AT jongwonlee roleofthehippocampalca1regioninincrementalvaluelearning AT inahlee roleofthehippocampalca1regioninincrementalvaluelearning AT minwhanjung roleofthehippocampalca1regioninincrementalvaluelearning
_version_	1718388251907063808

Role of the hippocampal CA1 region in incremental value learning

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