Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Abstract Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 BC cell lines cultured in both 2D and 3D conditions. A...

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Autores principales: Esmee Koedoot, Liesanne Wolters, Marcel Smid, Peter Stoilov, Gerhard A. Burger, Bram Herpers, Kuan Yan, Leo S. Price, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/57418be9999441f5885dc1b1785fe4d6
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