Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Sergio Luís Blay,1 João Vicente Augusto Aguiar,2 Ives Cavalcante Passos3 1Department of Psychiatry, Federal University of São Paulo (Escola Paulista de Medicina – UNIFESP), São Paulo, SP, Brazil; 2Department of Psychiatry, Fortaleza University,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Blay SL, Aguiar JV, Passos IC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	polycystic ovary syndrome depression anxiety epidemiological survey meta-analysis systematic review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/57480dc80c8f476eae961bfaa15ad646
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:57480dc80c8f476eae961bfaa15ad646
record_format	dspace
spelling	oai:doaj.org-article:57480dc80c8f476eae961bfaa15ad6462021-12-02T00:56:46ZPolycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis1178-2021https://doaj.org/article/57480dc80c8f476eae961bfaa15ad6462016-11-01T00:00:00Zhttps://www.dovepress.com/polycystic-ovary-syndrome-and-mental-disorders-a-systematic-review-and-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Sergio Luís Blay,1 João Vicente Augusto Aguiar,2 Ives Cavalcante Passos3 1Department of Psychiatry, Federal University of São Paulo (Escola Paulista de Medicina – UNIFESP), São Paulo, SP, Brazil; 2Department of Psychiatry, Fortaleza University, Fortaleza, Ceará, Brazil; 3Laboratory of Molecular Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil Background: The association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it. Methods: PubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive–compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models. Results: Six studies were included in the meta-analysis; of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76; 95% confidence interval (CI) 1.26 to 6.02; Log OR =1.013; P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR =3.51; 95% CI 1.97 to 6.24; Log OR =1.255; P<0.001). Conclusion: Anxiety and depression symptoms are more prevalent in patients with PCOS. Keywords: polycystic ovary syndrome, depression, anxiety, epidemiological survey, meta-analysis, systematic reviewBlay SLAguiar JVPassos ICDove Medical Pressarticlepolycystic ovary syndromedepressionanxietyepidemiological surveymeta-analysissystematic reviewNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2895-2903 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	polycystic ovary syndrome depression anxiety epidemiological survey meta-analysis systematic review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	polycystic ovary syndrome depression anxiety epidemiological survey meta-analysis systematic review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Blay SL Aguiar JV Passos IC Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
description	Sergio Luís Blay,1 João Vicente Augusto Aguiar,2 Ives Cavalcante Passos3 1Department of Psychiatry, Federal University of São Paulo (Escola Paulista de Medicina – UNIFESP), São Paulo, SP, Brazil; 2Department of Psychiatry, Fortaleza University, Fortaleza, Ceará, Brazil; 3Laboratory of Molecular Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil Background: The association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it. Methods: PubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive–compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models. Results: Six studies were included in the meta-analysis; of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76; 95% confidence interval (CI) 1.26 to 6.02; Log OR =1.013; P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR =3.51; 95% CI 1.97 to 6.24; Log OR =1.255; P<0.001). Conclusion: Anxiety and depression symptoms are more prevalent in patients with PCOS. Keywords: polycystic ovary syndrome, depression, anxiety, epidemiological survey, meta-analysis, systematic review
format	article
author	Blay SL Aguiar JV Passos IC
author_facet	Blay SL Aguiar JV Passos IC
author_sort	Blay SL
title	Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
title_short	Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
title_full	Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
title_fullStr	Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
title_full_unstemmed	Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
title_sort	polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/57480dc80c8f476eae961bfaa15ad646
work_keys_str_mv	AT blaysl polycysticovarysyndromeandmentaldisordersasystematicreviewandexploratorymetaanalysis AT aguiarjv polycysticovarysyndromeandmentaldisordersasystematicreviewandexploratorymetaanalysis AT passosic polycysticovarysyndromeandmentaldisordersasystematicreviewandexploratorymetaanalysis
_version_	1718403383265591296

Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Ejemplares similares