Macroglossia reveals multiple myeloma
We present an eighty-year old man with a one year history of progressive macroglossia, dysphagia and loss of weight. He had a medical history of arterial hypertension and prostatic hypertrophy which he had under good therapeutic control. The entire tongue was swollen, had hard solidity and was slig...
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PAGEPress Publications
2021
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oai:doaj.org-article:57490924173a428e8dce0ab62085895b2021-11-25T21:40:46ZMacroglossia reveals multiple myeloma10.4081/gc.2021.100072465-11092465-1397https://doaj.org/article/57490924173a428e8dce0ab62085895b2021-11-01T00:00:00Zhttps://www.pagepressjournals.org/index.php/gc/article/view/10007https://doaj.org/toc/2465-1109https://doaj.org/toc/2465-1397 We present an eighty-year old man with a one year history of progressive macroglossia, dysphagia and loss of weight. He had a medical history of arterial hypertension and prostatic hypertrophy which he had under good therapeutic control. The entire tongue was swollen, had hard solidity and was slightly painful upon palpation. A tongue biopsy revealed an amyloid deposition as it coloured bright orange-red on Congo Red staining and lead us subsequently to the diagnosis of amyloidosis; then a bone marrow biopsy confirmed the diagnosis of multiple myeloma. The case was further evaluated by a multidisciplinary team who considered it appropriate to start a lowdose melphalan treatment combined with supportive care. When macroglossia in the tongue is confirmed to be amyloidosis the differential diagnosis should include systemic amyloidosis deposition and multiple myeloma. Maria BonviciniDavide CrapanzanoSusanna FenuMarco GiordanoLorenzo PalleschiPAGEPress PublicationsarticleMacroglossiaamyloidosismultiple myeloma.GeriatricsRC952-954.6ENGeriatric Care, Vol 7, Iss 3 (2021) |
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Macroglossia amyloidosis multiple myeloma. Geriatrics RC952-954.6 |
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Macroglossia amyloidosis multiple myeloma. Geriatrics RC952-954.6 Maria Bonvicini Davide Crapanzano Susanna Fenu Marco Giordano Lorenzo Palleschi Macroglossia reveals multiple myeloma |
description |
We present an eighty-year old man with a one year history of progressive macroglossia, dysphagia and loss of weight. He had a medical history of arterial hypertension and prostatic hypertrophy which he had under good therapeutic control. The entire tongue was swollen, had hard solidity and was slightly painful upon palpation. A tongue biopsy revealed an amyloid deposition as it coloured bright orange-red on Congo Red staining and lead us subsequently to the diagnosis of amyloidosis; then a bone marrow biopsy confirmed the diagnosis of multiple myeloma. The case was further evaluated by a multidisciplinary team who considered it appropriate to start a lowdose melphalan treatment combined with supportive care. When macroglossia in the tongue is confirmed to be amyloidosis the differential diagnosis should include systemic amyloidosis deposition and multiple myeloma.
|
format |
article |
author |
Maria Bonvicini Davide Crapanzano Susanna Fenu Marco Giordano Lorenzo Palleschi |
author_facet |
Maria Bonvicini Davide Crapanzano Susanna Fenu Marco Giordano Lorenzo Palleschi |
author_sort |
Maria Bonvicini |
title |
Macroglossia reveals multiple myeloma |
title_short |
Macroglossia reveals multiple myeloma |
title_full |
Macroglossia reveals multiple myeloma |
title_fullStr |
Macroglossia reveals multiple myeloma |
title_full_unstemmed |
Macroglossia reveals multiple myeloma |
title_sort |
macroglossia reveals multiple myeloma |
publisher |
PAGEPress Publications |
publishDate |
2021 |
url |
https://doaj.org/article/57490924173a428e8dce0ab62085895b |
work_keys_str_mv |
AT mariabonvicini macroglossiarevealsmultiplemyeloma AT davidecrapanzano macroglossiarevealsmultiplemyeloma AT susannafenu macroglossiarevealsmultiplemyeloma AT marcogiordano macroglossiarevealsmultiplemyeloma AT lorenzopalleschi macroglossiarevealsmultiplemyeloma |
_version_ |
1718410030714191872 |