Macroglossia reveals multiple myeloma

We present an eighty-year old man with a one year history of progressive macroglossia, dysphagia and loss of weight. He had a medical history of arterial hypertension and prostatic hypertrophy which he had under good therapeutic control. The entire tongue was swollen, had hard solidity and was slig...

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Autores principales: Maria Bonvicini, Davide Crapanzano, Susanna Fenu, Marco Giordano, Lorenzo Palleschi
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Lenguaje:EN
Publicado: PAGEPress Publications 2021
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Acceso en línea:https://doaj.org/article/57490924173a428e8dce0ab62085895b
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spelling oai:doaj.org-article:57490924173a428e8dce0ab62085895b2021-11-25T21:40:46ZMacroglossia reveals multiple myeloma10.4081/gc.2021.100072465-11092465-1397https://doaj.org/article/57490924173a428e8dce0ab62085895b2021-11-01T00:00:00Zhttps://www.pagepressjournals.org/index.php/gc/article/view/10007https://doaj.org/toc/2465-1109https://doaj.org/toc/2465-1397 We present an eighty-year old man with a one year history of progressive macroglossia, dysphagia and loss of weight. He had a medical history of arterial hypertension and prostatic hypertrophy which he had under good therapeutic control. The entire tongue was swollen, had hard solidity and was slightly painful upon palpation. A tongue biopsy revealed an amyloid deposition as it coloured bright orange-red on Congo Red staining and lead us subsequently to the diagnosis of amyloidosis; then a bone marrow biopsy confirmed the diagnosis of multiple myeloma. The case was further evaluated by a multidisciplinary team who considered it appropriate to start a lowdose melphalan treatment combined with supportive care. When macroglossia in the tongue is confirmed to be amyloidosis the differential diagnosis should include systemic amyloidosis deposition and multiple myeloma. Maria BonviciniDavide CrapanzanoSusanna FenuMarco GiordanoLorenzo PalleschiPAGEPress PublicationsarticleMacroglossiaamyloidosismultiple myeloma.GeriatricsRC952-954.6ENGeriatric Care, Vol 7, Iss 3 (2021)
institution DOAJ
collection DOAJ
language EN
topic Macroglossia
amyloidosis
multiple myeloma.
Geriatrics
RC952-954.6
spellingShingle Macroglossia
amyloidosis
multiple myeloma.
Geriatrics
RC952-954.6
Maria Bonvicini
Davide Crapanzano
Susanna Fenu
Marco Giordano
Lorenzo Palleschi
Macroglossia reveals multiple myeloma
description We present an eighty-year old man with a one year history of progressive macroglossia, dysphagia and loss of weight. He had a medical history of arterial hypertension and prostatic hypertrophy which he had under good therapeutic control. The entire tongue was swollen, had hard solidity and was slightly painful upon palpation. A tongue biopsy revealed an amyloid deposition as it coloured bright orange-red on Congo Red staining and lead us subsequently to the diagnosis of amyloidosis; then a bone marrow biopsy confirmed the diagnosis of multiple myeloma. The case was further evaluated by a multidisciplinary team who considered it appropriate to start a lowdose melphalan treatment combined with supportive care. When macroglossia in the tongue is confirmed to be amyloidosis the differential diagnosis should include systemic amyloidosis deposition and multiple myeloma.
format article
author Maria Bonvicini
Davide Crapanzano
Susanna Fenu
Marco Giordano
Lorenzo Palleschi
author_facet Maria Bonvicini
Davide Crapanzano
Susanna Fenu
Marco Giordano
Lorenzo Palleschi
author_sort Maria Bonvicini
title Macroglossia reveals multiple myeloma
title_short Macroglossia reveals multiple myeloma
title_full Macroglossia reveals multiple myeloma
title_fullStr Macroglossia reveals multiple myeloma
title_full_unstemmed Macroglossia reveals multiple myeloma
title_sort macroglossia reveals multiple myeloma
publisher PAGEPress Publications
publishDate 2021
url https://doaj.org/article/57490924173a428e8dce0ab62085895b
work_keys_str_mv AT mariabonvicini macroglossiarevealsmultiplemyeloma
AT davidecrapanzano macroglossiarevealsmultiplemyeloma
AT susannafenu macroglossiarevealsmultiplemyeloma
AT marcogiordano macroglossiarevealsmultiplemyeloma
AT lorenzopalleschi macroglossiarevealsmultiplemyeloma
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