Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study

In this single-arm pilot open-label study we examined the effect of a mindfulness-based intervention on reduction of headache frequency after 12 months in adolescents aged 12–18 with chronic or high-frequency migraine without aura. Adolescents were recruited at the headache center of the C. Besta Ne...

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Autores principales:	Licia Grazzi, Eleonora Grignani, Alberto Raggi, Paul Rizzoli, Erika Guastafierro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	headache mindfulness adolescents chronic migraine disability anxiety Medicine R
Acceso en línea:	https://doaj.org/article/574e6801d1e248749147a2c1fdf5cda2
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spelling	oai:doaj.org-article:574e6801d1e248749147a2c1fdf5cda22021-11-25T17:47:52ZEffect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study10.3390/ijerph1822117391660-46011661-7827https://doaj.org/article/574e6801d1e248749147a2c1fdf5cda22021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11739https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601In this single-arm pilot open-label study we examined the effect of a mindfulness-based intervention on reduction of headache frequency after 12 months in adolescents aged 12–18 with chronic or high-frequency migraine without aura. Adolescents were recruited at the headache center of the C. Besta Neurological Institute and followed-up for 12 months. The mindfulness-based intervention was delivered in small groups and consisted of six weekly group sessions of guided meditation, and one booster session 15 days after. Patients filled in questionnaires assessing headache frequency (primary endpoint), medication intake, disability, anxiety, depression, catastrophizing, and caregivers’ burden. Within-person ANOVA was used to address variation of endpoints over time. Thirty-five out of 37 patients completed the study for primary endpoints, and 33 for secondary endpoints. Headache frequency dropped from 21.3 (95% CI 18.5; 24.1) to 9.6 (95% CI 6.1; 13.1) days per month at 12 months (F = 30.5, <i>p</i> < 0.001); 23 patients out of 35 (65.7%) achieved a headache frequency reduction greater than or equal to 50%. Significant improvements were also reported for medication intake (F = 18.7, <i>p</i> < 0.001), disability (F = 3.8, <i>p</i> = 0.027), trait anxiety (F = 5.1, <i>p</i> = 0.009), symptoms of depression (F = 9.5, <i>p</i> < 0.001), and catastrophizing (F = 23.6, <i>p</i> < 0.001). In conclusions, our study shows a reduction of headache attacks in adolescents who follow a mindfulness-based program, suggesting benefit of this nonpharmacological approach.Licia GrazziEleonora GrignaniAlberto RaggiPaul RizzoliErika GuastafierroMDPI AGarticleheadachemindfulnessadolescentschronic migrainedisabilityanxietyMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11739, p 11739 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	headache mindfulness adolescents chronic migraine disability anxiety Medicine R
spellingShingle	headache mindfulness adolescents chronic migraine disability anxiety Medicine R Licia Grazzi Eleonora Grignani Alberto Raggi Paul Rizzoli Erika Guastafierro Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study
description	In this single-arm pilot open-label study we examined the effect of a mindfulness-based intervention on reduction of headache frequency after 12 months in adolescents aged 12–18 with chronic or high-frequency migraine without aura. Adolescents were recruited at the headache center of the C. Besta Neurological Institute and followed-up for 12 months. The mindfulness-based intervention was delivered in small groups and consisted of six weekly group sessions of guided meditation, and one booster session 15 days after. Patients filled in questionnaires assessing headache frequency (primary endpoint), medication intake, disability, anxiety, depression, catastrophizing, and caregivers’ burden. Within-person ANOVA was used to address variation of endpoints over time. Thirty-five out of 37 patients completed the study for primary endpoints, and 33 for secondary endpoints. Headache frequency dropped from 21.3 (95% CI 18.5; 24.1) to 9.6 (95% CI 6.1; 13.1) days per month at 12 months (F = 30.5, <i>p</i> < 0.001); 23 patients out of 35 (65.7%) achieved a headache frequency reduction greater than or equal to 50%. Significant improvements were also reported for medication intake (F = 18.7, <i>p</i> < 0.001), disability (F = 3.8, <i>p</i> = 0.027), trait anxiety (F = 5.1, <i>p</i> = 0.009), symptoms of depression (F = 9.5, <i>p</i> < 0.001), and catastrophizing (F = 23.6, <i>p</i> < 0.001). In conclusions, our study shows a reduction of headache attacks in adolescents who follow a mindfulness-based program, suggesting benefit of this nonpharmacological approach.
format	article
author	Licia Grazzi Eleonora Grignani Alberto Raggi Paul Rizzoli Erika Guastafierro
author_facet	Licia Grazzi Eleonora Grignani Alberto Raggi Paul Rizzoli Erika Guastafierro
author_sort	Licia Grazzi
title	Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study
title_short	Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study
title_full	Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study
title_fullStr	Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study
title_full_unstemmed	Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study
title_sort	effect of a mindfulness-based intervention for chronic migraine and high frequency episodic migraine in adolescents: a pilot single-arm open-label study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/574e6801d1e248749147a2c1fdf5cda2
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Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study

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