A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.

<h4>Objective</h4>A meta-analysis was applied to evaluate the associations between tumor necrosis factor-α (TNF-α) -308G>A (rs1800629) polymorphism and type 2 diabetes mellitus (T2DM).<h4>Methods</h4>Hardy-Weinberg equilibrium (HWE) was employed to test genetic equilibrium...

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Autores principales:	Zheng-hui Liu, Yuan-lin Ding, Liang-chang Xiu, Hai-yan Pan, Yan Liang, Shou-qiang Zhong, Wei-wei Liu, Shao-qi Rao, Dan-li Kong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/574f11550b5f4d7083471e022ae6327f
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spelling	oai:doaj.org-article:574f11550b5f4d7083471e022ae6327f2021-11-18T07:52:50ZA meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.1932-620310.1371/journal.pone.0059421https://doaj.org/article/574f11550b5f4d7083471e022ae6327f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527193/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>A meta-analysis was applied to evaluate the associations between tumor necrosis factor-α (TNF-α) -308G>A (rs1800629) polymorphism and type 2 diabetes mellitus (T2DM).<h4>Methods</h4>Hardy-Weinberg equilibrium (HWE) was employed to test genetic equilibrium among the genotypes of the selected literature. Power analysis was performed with the Power and Sample Size Calculation (PS) program. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with the Begg's funnel plot test and Egger's linear regression test. The meta-analysis was performed with Review Manager 5.1 and Stata 11.0.<h4>Results</h4>There were 10 studies including 1425 T2DM patients and 1116 healthy control subjects involved in this meta-analysis. No significant publication bias was found in the studies. The pooled ORs (95% CIs) for TNF-α -308G>A of A vs. G allele and GA+AA vs. GG genotype were 1.63 (1.17-2.25) and 1.47 (1.17-1.85), respectively.<h4>Conclusion</h4>This meta-analysis result suggested that TNF-α -308G>A polymorphism was strongly associated with T2DM risk, and A allele at this locus might be a susceptibility allele for the development of T2DM in Han Chinese population.Zheng-hui LiuYuan-lin DingLiang-chang XiuHai-yan PanYan LiangShou-qiang ZhongWei-wei LiuShao-qi RaoDan-li KongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59421 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheng-hui Liu Yuan-lin Ding Liang-chang Xiu Hai-yan Pan Yan Liang Shou-qiang Zhong Wei-wei Liu Shao-qi Rao Dan-li Kong A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.
description	<h4>Objective</h4>A meta-analysis was applied to evaluate the associations between tumor necrosis factor-α (TNF-α) -308G>A (rs1800629) polymorphism and type 2 diabetes mellitus (T2DM).<h4>Methods</h4>Hardy-Weinberg equilibrium (HWE) was employed to test genetic equilibrium among the genotypes of the selected literature. Power analysis was performed with the Power and Sample Size Calculation (PS) program. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with the Begg's funnel plot test and Egger's linear regression test. The meta-analysis was performed with Review Manager 5.1 and Stata 11.0.<h4>Results</h4>There were 10 studies including 1425 T2DM patients and 1116 healthy control subjects involved in this meta-analysis. No significant publication bias was found in the studies. The pooled ORs (95% CIs) for TNF-α -308G>A of A vs. G allele and GA+AA vs. GG genotype were 1.63 (1.17-2.25) and 1.47 (1.17-1.85), respectively.<h4>Conclusion</h4>This meta-analysis result suggested that TNF-α -308G>A polymorphism was strongly associated with T2DM risk, and A allele at this locus might be a susceptibility allele for the development of T2DM in Han Chinese population.
format	article
author	Zheng-hui Liu Yuan-lin Ding Liang-chang Xiu Hai-yan Pan Yan Liang Shou-qiang Zhong Wei-wei Liu Shao-qi Rao Dan-li Kong
author_facet	Zheng-hui Liu Yuan-lin Ding Liang-chang Xiu Hai-yan Pan Yan Liang Shou-qiang Zhong Wei-wei Liu Shao-qi Rao Dan-li Kong
author_sort	Zheng-hui Liu
title	A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.
title_short	A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.
title_full	A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.
title_fullStr	A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.
title_full_unstemmed	A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.
title_sort	meta-analysis of the association between tnf-α -308g>a polymorphism and type 2 diabetes mellitus in han chinese population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/574f11550b5f4d7083471e022ae6327f
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A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.

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