Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells

Abstract The junctional epithelium (JE) is an epithelial component that attaches directly to the tooth surface and performs the unique function of protecting against bacterial infections; its destruction causes inflammation of the periodontal tissue and loss of alveolar bone. A recent study that use...

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Autores principales:	Keisuke Tanaka, Junichi Tanaka, Ryo Aizawa, Mayu Kato-Tanaka, Hiroo Ueno, Kenji Mishima, Matsuo Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/575315c14c354515b51004ea6578055b
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spelling	oai:doaj.org-article:575315c14c354515b51004ea6578055b2021-12-02T18:13:53ZStructure of junctional epithelium is maintained by cell populations supplied from multiple stem cells10.1038/s41598-021-98398-72045-2322https://doaj.org/article/575315c14c354515b51004ea6578055b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98398-7https://doaj.org/toc/2045-2322Abstract The junctional epithelium (JE) is an epithelial component that attaches directly to the tooth surface and performs the unique function of protecting against bacterial infections; its destruction causes inflammation of the periodontal tissue and loss of alveolar bone. A recent study that used the single-color lineage tracing method reported that JE is maintained by its stem cells. However, the process by which individual stem cells form the entire JE around a whole tooth remains unclear. Using a 4-color lineage tracing method, we performed a detailed examination of the dynamics of individual stem cells that constitute the entire JE. The multicolor lineage tracing method showed that single-color areas, which were derived from each cell color, replaced all the constituent JE cells 168 d after the administration of tamoxifen. The horizontal section of the first molar showed that the single-color areas in the JE expanded widely. We detected putative stem cells at the external basal layer farthest from the enamel. In this study, JE cells that were supplied from different stem cells were visualized as individual monochromatic regions, and the JE around the first molar was maintained by several JE-specific stem cells. These findings indicated that the JE consisted of several cell populations that were supplied from their multiple stem cells and could help to explore the mechanisms involved in periodontal tissue homeostasis.Keisuke TanakaJunichi TanakaRyo AizawaMayu Kato-TanakaHiroo UenoKenji MishimaMatsuo YamamotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keisuke Tanaka Junichi Tanaka Ryo Aizawa Mayu Kato-Tanaka Hiroo Ueno Kenji Mishima Matsuo Yamamoto Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells
description	Abstract The junctional epithelium (JE) is an epithelial component that attaches directly to the tooth surface and performs the unique function of protecting against bacterial infections; its destruction causes inflammation of the periodontal tissue and loss of alveolar bone. A recent study that used the single-color lineage tracing method reported that JE is maintained by its stem cells. However, the process by which individual stem cells form the entire JE around a whole tooth remains unclear. Using a 4-color lineage tracing method, we performed a detailed examination of the dynamics of individual stem cells that constitute the entire JE. The multicolor lineage tracing method showed that single-color areas, which were derived from each cell color, replaced all the constituent JE cells 168 d after the administration of tamoxifen. The horizontal section of the first molar showed that the single-color areas in the JE expanded widely. We detected putative stem cells at the external basal layer farthest from the enamel. In this study, JE cells that were supplied from different stem cells were visualized as individual monochromatic regions, and the JE around the first molar was maintained by several JE-specific stem cells. These findings indicated that the JE consisted of several cell populations that were supplied from their multiple stem cells and could help to explore the mechanisms involved in periodontal tissue homeostasis.
format	article
author	Keisuke Tanaka Junichi Tanaka Ryo Aizawa Mayu Kato-Tanaka Hiroo Ueno Kenji Mishima Matsuo Yamamoto
author_facet	Keisuke Tanaka Junichi Tanaka Ryo Aizawa Mayu Kato-Tanaka Hiroo Ueno Kenji Mishima Matsuo Yamamoto
author_sort	Keisuke Tanaka
title	Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells
title_short	Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells
title_full	Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells
title_fullStr	Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells
title_full_unstemmed	Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells
title_sort	structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/575315c14c354515b51004ea6578055b
work_keys_str_mv	AT keisuketanaka structureofjunctionalepitheliumismaintainedbycellpopulationssuppliedfrommultiplestemcells AT junichitanaka structureofjunctionalepitheliumismaintainedbycellpopulationssuppliedfrommultiplestemcells AT ryoaizawa structureofjunctionalepitheliumismaintainedbycellpopulationssuppliedfrommultiplestemcells AT mayukatotanaka structureofjunctionalepitheliumismaintainedbycellpopulationssuppliedfrommultiplestemcells AT hirooueno structureofjunctionalepitheliumismaintainedbycellpopulationssuppliedfrommultiplestemcells AT kenjimishima structureofjunctionalepitheliumismaintainedbycellpopulationssuppliedfrommultiplestemcells AT matsuoyamamoto structureofjunctionalepitheliumismaintainedbycellpopulationssuppliedfrommultiplestemcells
_version_	1718378452583710720

Structure of junctional epithelium is maintained by cell populations supplied from multiple stem cells

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