Control of dendritic morphogenesis by Trio in Drosophila melanogaster.

Abl tyrosine kinase and its effectors among the Rho family of GTPases each act to control dendritic morphogenesis in Drosophila. It has not been established, however, which of the many GTPase regulators in the cell link these signaling molecules in the dendrite. In axons, the bifunctional guanine ex...

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Autores principales:	Madhuri Shivalkar, Edward Giniger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/575820ce72864d0f911a5981095ce71e
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spelling	oai:doaj.org-article:575820ce72864d0f911a5981095ce71e2021-11-18T07:25:04ZControl of dendritic morphogenesis by Trio in Drosophila melanogaster.1932-620310.1371/journal.pone.0033737https://doaj.org/article/575820ce72864d0f911a5981095ce71e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22438988/?tool=EBIhttps://doaj.org/toc/1932-6203Abl tyrosine kinase and its effectors among the Rho family of GTPases each act to control dendritic morphogenesis in Drosophila. It has not been established, however, which of the many GTPase regulators in the cell link these signaling molecules in the dendrite. In axons, the bifunctional guanine exchange factor, Trio, is an essential link between the Abl tyrosine kinase signaling pathway and Rho GTPases, particularly Rac, allowing these systems to act coordinately to control actin organization. In dendritic morphogenesis, however, Abl and Rac have contrary rather than reinforcing effects, raising the question of whether Trio is involved, and if so, whether it acts through Rac, Rho or both. We now find that Trio is expressed in sensory neurons of the Drosophila embryo and regulates their dendritic arborization. trio mutants display a reduction in dendritic branching and increase in average branch length, whereas over-expression of trio has the opposite effect. We further show that it is the Rac GEF domain of Trio, and not its Rho GEF domain that is primarily responsible for the dendritic function of Trio. Thus, Trio shapes the complexity of dendritic arbors and does so in a way that mimics the effects of its target, Rac.Madhuri ShivalkarEdward GinigerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33737 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Madhuri Shivalkar Edward Giniger Control of dendritic morphogenesis by Trio in Drosophila melanogaster.
description	Abl tyrosine kinase and its effectors among the Rho family of GTPases each act to control dendritic morphogenesis in Drosophila. It has not been established, however, which of the many GTPase regulators in the cell link these signaling molecules in the dendrite. In axons, the bifunctional guanine exchange factor, Trio, is an essential link between the Abl tyrosine kinase signaling pathway and Rho GTPases, particularly Rac, allowing these systems to act coordinately to control actin organization. In dendritic morphogenesis, however, Abl and Rac have contrary rather than reinforcing effects, raising the question of whether Trio is involved, and if so, whether it acts through Rac, Rho or both. We now find that Trio is expressed in sensory neurons of the Drosophila embryo and regulates their dendritic arborization. trio mutants display a reduction in dendritic branching and increase in average branch length, whereas over-expression of trio has the opposite effect. We further show that it is the Rac GEF domain of Trio, and not its Rho GEF domain that is primarily responsible for the dendritic function of Trio. Thus, Trio shapes the complexity of dendritic arbors and does so in a way that mimics the effects of its target, Rac.
format	article
author	Madhuri Shivalkar Edward Giniger
author_facet	Madhuri Shivalkar Edward Giniger
author_sort	Madhuri Shivalkar
title	Control of dendritic morphogenesis by Trio in Drosophila melanogaster.
title_short	Control of dendritic morphogenesis by Trio in Drosophila melanogaster.
title_full	Control of dendritic morphogenesis by Trio in Drosophila melanogaster.
title_fullStr	Control of dendritic morphogenesis by Trio in Drosophila melanogaster.
title_full_unstemmed	Control of dendritic morphogenesis by Trio in Drosophila melanogaster.
title_sort	control of dendritic morphogenesis by trio in drosophila melanogaster.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/575820ce72864d0f911a5981095ce71e
work_keys_str_mv	AT madhurishivalkar controlofdendriticmorphogenesisbytrioindrosophilamelanogaster AT edwardginiger controlofdendriticmorphogenesisbytrioindrosophilamelanogaster
_version_	1718423475724484608

Control of dendritic morphogenesis by Trio in Drosophila melanogaster.

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