Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP

Manganese (Mn) is an essential trace element required for various biological processes. However, excess Mn causes serious side effects in humans, including parkinsonism. Thus, elucidation of Mn homeostasis at the systemic, cellular, and molecular levels is important. Many metal transporters and chan...

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Autores principales:	Hitomi Fujishiro, Taiho Kambe
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Manganese ZNT ZIP Zinc Transporter Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/57584a243d184ee395fd8f0d5e7b77cf
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spelling	oai:doaj.org-article:57584a243d184ee395fd8f0d5e7b77cf2021-11-20T04:57:30ZManganese transport in mammals by zinc transporter family proteins, ZNT and ZIP1347-861310.1016/j.jphs.2021.10.011https://doaj.org/article/57584a243d184ee395fd8f0d5e7b77cf2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1347861321001067https://doaj.org/toc/1347-8613Manganese (Mn) is an essential trace element required for various biological processes. However, excess Mn causes serious side effects in humans, including parkinsonism. Thus, elucidation of Mn homeostasis at the systemic, cellular, and molecular levels is important. Many metal transporters and channels can be involved in the transport and homeostasis of Mn, and an increasing body of evidence shows that several zinc (Zn) transporters belonging to the ZIP and ZNT families, specifically, ZNT10, ZIP8, and ZIP14, play pivotal roles in Mn metabolism. Mutations in the genes encoding these transporter proteins are associated with congenital disorders related to dysregulated Mn homeostasis in humans. Moreover, single nucleotide polymorphisms of ZIP8 are associated with multiple clinical phenotypes. In this review, we discuss the recent literature on the structural and biochemical features of ZNT10, ZIP8, and ZIP14, including transport mechanisms, regulation of expression, and pathophysiological functions. Because a disturbance in Mn homeostasis is closely associated with a variety of phenotypes and risk of human diseases, these transporters constitute a significant target for drug development. An understanding of the roles of these key transporters in Mn metabolism should provide new insights into pharmacological applications of their inhibitors and enhancers in human diseases.Hitomi FujishiroTaiho KambeElsevierarticleManganeseZNTZIPZincTransporterTherapeutics. PharmacologyRM1-950ENJournal of Pharmacological Sciences, Vol 148, Iss 1, Pp 125-133 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Manganese ZNT ZIP Zinc Transporter Therapeutics. Pharmacology RM1-950
spellingShingle	Manganese ZNT ZIP Zinc Transporter Therapeutics. Pharmacology RM1-950 Hitomi Fujishiro Taiho Kambe Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
description	Manganese (Mn) is an essential trace element required for various biological processes. However, excess Mn causes serious side effects in humans, including parkinsonism. Thus, elucidation of Mn homeostasis at the systemic, cellular, and molecular levels is important. Many metal transporters and channels can be involved in the transport and homeostasis of Mn, and an increasing body of evidence shows that several zinc (Zn) transporters belonging to the ZIP and ZNT families, specifically, ZNT10, ZIP8, and ZIP14, play pivotal roles in Mn metabolism. Mutations in the genes encoding these transporter proteins are associated with congenital disorders related to dysregulated Mn homeostasis in humans. Moreover, single nucleotide polymorphisms of ZIP8 are associated with multiple clinical phenotypes. In this review, we discuss the recent literature on the structural and biochemical features of ZNT10, ZIP8, and ZIP14, including transport mechanisms, regulation of expression, and pathophysiological functions. Because a disturbance in Mn homeostasis is closely associated with a variety of phenotypes and risk of human diseases, these transporters constitute a significant target for drug development. An understanding of the roles of these key transporters in Mn metabolism should provide new insights into pharmacological applications of their inhibitors and enhancers in human diseases.
format	article
author	Hitomi Fujishiro Taiho Kambe
author_facet	Hitomi Fujishiro Taiho Kambe
author_sort	Hitomi Fujishiro
title	Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
title_short	Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
title_full	Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
title_fullStr	Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
title_full_unstemmed	Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP
title_sort	manganese transport in mammals by zinc transporter family proteins, znt and zip
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/57584a243d184ee395fd8f0d5e7b77cf
work_keys_str_mv	AT hitomifujishiro manganesetransportinmammalsbyzinctransporterfamilyproteinszntandzip AT taihokambe manganesetransportinmammalsbyzinctransporterfamilyproteinszntandzip
_version_	1718419715097886720

Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP

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