GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

Aims. This meta-analysis of randomized placebo-controlled clinical trials assessed the effect of glucose-like peptide-1-receptor agonists (GLP-1RA) on the lipid profile and liver enzymes in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods. Randomized placebo-controlled t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shahla Rezaei, Reza Tabrizi, Peyman Nowrouzi-Sohrabi, Mohammad Jalali, Stephen L. Atkin, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/575902276a12457aaf5580741dcd481a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:575902276a12457aaf5580741dcd481a
record_format	dspace
spelling	oai:doaj.org-article:575902276a12457aaf5580741dcd481a2021-11-22T01:10:08ZGLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis2291-279710.1155/2021/8936865https://doaj.org/article/575902276a12457aaf5580741dcd481a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8936865https://doaj.org/toc/2291-2797Aims. This meta-analysis of randomized placebo-controlled clinical trials assessed the effect of glucose-like peptide-1-receptor agonists (GLP-1RA) on the lipid profile and liver enzymes in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods. Randomized placebo-controlled trials investigating GLP-1RA on the lipid profile and liver enzymes in patients with NAFLD were searched in PubMed-Medline, Scopus, Web of Science, and Google Scholar databases (from inception to January 2020). A random-effects model and a generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted. Weighted random-effects meta-regression was performed on potential confounders on lipid profile and liver enzyme concentrations. Results. 12 studies were identified (12 GLP-1RA arms; 677 subjects) that showed treatment with GLP-1RA reduced alanine transaminase (ALT) concentrations (WMD = −10.14, 95%CI = [−15.84, −0.44], P<0.001), gamma-glutamyl transferase (GGT) (WMD = −11.53, 95%CI = [−15.21,−7.85], P<0.001), and alaline phosphatase (ALP) (WMD = −8.29, 95%CI = [−11.34, −5.24], P<0.001). Aspartate aminotransferase (AST) (WMD = −2.95, 95% CI = [−7.26, 1.37], P=0.18) was unchanged. GLP-1 therapy did not alter triglycerides (TC) (WMD = −7.07, 95%CI = [−17.51, 3.37], P=0.18), total cholesterol (TC) (WMD = −1.17 (−5.25, 2.91), P=0.57), high-density lipoprotein (HDL-C) (WMD = 0.97, 95%CI = [−1.63, 3.58], P=0.46), or low-density lipoprotein (LDL-C) (WMD = −1.67, 95%CI = [−10.08, 6.74], P=0.69) in comparison with controls. Conclusion. The results of this meta-analysis suggest that GLP-1RA treatment significantly reduces liver enzymes in patients with NAFLD, but the lipid profile is unaffected.Shahla RezaeiReza TabriziPeyman Nowrouzi-SohrabiMohammad JalaliStephen L. AtkinKhalid Al-RasadiTannaz JamialahmadiAmirhossein SahebkarHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENCanadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Shahla Rezaei Reza Tabrizi Peyman Nowrouzi-Sohrabi Mohammad Jalali Stephen L. Atkin Khalid Al-Rasadi Tannaz Jamialahmadi Amirhossein Sahebkar GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
description	Aims. This meta-analysis of randomized placebo-controlled clinical trials assessed the effect of glucose-like peptide-1-receptor agonists (GLP-1RA) on the lipid profile and liver enzymes in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods. Randomized placebo-controlled trials investigating GLP-1RA on the lipid profile and liver enzymes in patients with NAFLD were searched in PubMed-Medline, Scopus, Web of Science, and Google Scholar databases (from inception to January 2020). A random-effects model and a generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted. Weighted random-effects meta-regression was performed on potential confounders on lipid profile and liver enzyme concentrations. Results. 12 studies were identified (12 GLP-1RA arms; 677 subjects) that showed treatment with GLP-1RA reduced alanine transaminase (ALT) concentrations (WMD = −10.14, 95%CI = [−15.84, −0.44], P<0.001), gamma-glutamyl transferase (GGT) (WMD = −11.53, 95%CI = [−15.21,−7.85], P<0.001), and alaline phosphatase (ALP) (WMD = −8.29, 95%CI = [−11.34, −5.24], P<0.001). Aspartate aminotransferase (AST) (WMD = −2.95, 95% CI = [−7.26, 1.37], P=0.18) was unchanged. GLP-1 therapy did not alter triglycerides (TC) (WMD = −7.07, 95%CI = [−17.51, 3.37], P=0.18), total cholesterol (TC) (WMD = −1.17 (−5.25, 2.91), P=0.57), high-density lipoprotein (HDL-C) (WMD = 0.97, 95%CI = [−1.63, 3.58], P=0.46), or low-density lipoprotein (LDL-C) (WMD = −1.67, 95%CI = [−10.08, 6.74], P=0.69) in comparison with controls. Conclusion. The results of this meta-analysis suggest that GLP-1RA treatment significantly reduces liver enzymes in patients with NAFLD, but the lipid profile is unaffected.
format	article
author	Shahla Rezaei Reza Tabrizi Peyman Nowrouzi-Sohrabi Mohammad Jalali Stephen L. Atkin Khalid Al-Rasadi Tannaz Jamialahmadi Amirhossein Sahebkar
author_facet	Shahla Rezaei Reza Tabrizi Peyman Nowrouzi-Sohrabi Mohammad Jalali Stephen L. Atkin Khalid Al-Rasadi Tannaz Jamialahmadi Amirhossein Sahebkar
author_sort	Shahla Rezaei
title	GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
title_short	GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
title_full	GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
title_fullStr	GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
title_full_unstemmed	GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
title_sort	glp-1 receptor agonist effects on lipid and liver profiles in patients with nonalcoholic fatty liver disease: systematic review and meta-analysis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/575902276a12457aaf5580741dcd481a
work_keys_str_mv	AT shahlarezaei glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis AT rezatabrizi glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis AT peymannowrouzisohrabi glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis AT mohammadjalali glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis AT stephenlatkin glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis AT khalidalrasadi glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis AT tannazjamialahmadi glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis AT amirhosseinsahebkar glp1receptoragonisteffectsonlipidandliverprofilesinpatientswithnonalcoholicfattyliverdiseasesystematicreviewandmetaanalysis
_version_	1718418400885080064

GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

Ejemplares similares