IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation

Abstract BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Roee Dvir, Vera Paloschi, Filippo Canducci, Giacomo Dell’Antonio, Sara Racca, Rossana Caldara, Giuseppe Pantaleo, Massimo Clementi, Antonio Secchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57593747d32040b285544e6ceacad372
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:57593747d32040b285544e6ceacad372
record_format	dspace
spelling	oai:doaj.org-article:57593747d32040b285544e6ceacad3722021-12-02T12:32:08ZIL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation10.1038/s41598-017-06915-42045-2322https://doaj.org/article/57593747d32040b285544e6ceacad3722017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06915-4https://doaj.org/toc/2045-2322Abstract BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific protection of the epithelia. We aimed to test the hypothesis of correlation between a single nucleotide polymorphism (C/T dimorphism rs12979860) in the genomic region of IL28B and BKVAN, in patients after KT. Fifty kidney-transplanted patients were included as follow: Group 1 (BKV+/BKVAN+): 11 patients with active BKV− replication and biopsy-proven BKVAN; Group 2 (BKV+/BKVAN−): 22 patients with active BKV− replication but without evidence of BKVAN; Group 3 (BKV−/BKVAN−): 17 patients without evidence of BKV− replication (control group). Here we show that the C/C genotype was statistically higher in group 2 than in group 1 and BKVAN was detected significantly more frequently in patients with C/T and T/T genotypes than in patients with C/C genotype. We therefore propose IL28B polymorphism (rs12979860), as a predictor-marker to differentiate between patients with self-limited, even if persistent, BKV− reactivation and patients with a high risk of progression towards BKVAN, and to modulate the clinical management of these patients accordingly.Roee DvirVera PaloschiFilippo CanducciGiacomo Dell’AntonioSara RaccaRossana CaldaraGiuseppe PantaleoMassimo ClementiAntonio SecchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roee Dvir Vera Paloschi Filippo Canducci Giacomo Dell’Antonio Sara Racca Rossana Caldara Giuseppe Pantaleo Massimo Clementi Antonio Secchi IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation
description	Abstract BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific protection of the epithelia. We aimed to test the hypothesis of correlation between a single nucleotide polymorphism (C/T dimorphism rs12979860) in the genomic region of IL28B and BKVAN, in patients after KT. Fifty kidney-transplanted patients were included as follow: Group 1 (BKV+/BKVAN+): 11 patients with active BKV− replication and biopsy-proven BKVAN; Group 2 (BKV+/BKVAN−): 22 patients with active BKV− replication but without evidence of BKVAN; Group 3 (BKV−/BKVAN−): 17 patients without evidence of BKV− replication (control group). Here we show that the C/C genotype was statistically higher in group 2 than in group 1 and BKVAN was detected significantly more frequently in patients with C/T and T/T genotypes than in patients with C/C genotype. We therefore propose IL28B polymorphism (rs12979860), as a predictor-marker to differentiate between patients with self-limited, even if persistent, BKV− reactivation and patients with a high risk of progression towards BKVAN, and to modulate the clinical management of these patients accordingly.
format	article
author	Roee Dvir Vera Paloschi Filippo Canducci Giacomo Dell’Antonio Sara Racca Rossana Caldara Giuseppe Pantaleo Massimo Clementi Antonio Secchi
author_facet	Roee Dvir Vera Paloschi Filippo Canducci Giacomo Dell’Antonio Sara Racca Rossana Caldara Giuseppe Pantaleo Massimo Clementi Antonio Secchi
author_sort	Roee Dvir
title	IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation
title_short	IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation
title_full	IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation
title_fullStr	IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation
title_full_unstemmed	IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation
title_sort	il28b rs12979860 genotype as a predictor marker of progression to bkvirus associated nephropathy, after kidney transplantation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/57593747d32040b285544e6ceacad372
work_keys_str_mv	AT roeedvir il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT verapaloschi il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT filippocanducci il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT giacomodellantonio il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT sararacca il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT rossanacaldara il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT giuseppepantaleo il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT massimoclementi il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation AT antoniosecchi il28brs12979860genotypeasapredictormarkerofprogressiontobkvirusassociatednephropathyafterkidneytransplantation
_version_	1718394156991119360

IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation

Ejemplares similares