Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study

Abstract Background: Portulaca oleracea (PO) is a widely known plant utilized for its medicinal attributes in the treatment of different illnesses. Objective: To investigate the effect of methanolic extract of PO (MEPO) on ovariectomy-induced reproductive toxicity in normal cyclic rats. Materials an...

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Autores principales:	Izuchukwu Azuka Okafor, Uchenna Somtochukwu Okafor, Victor Ndukwe
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Sadoughi University of Medical Sciences 2021
Materias:	portulaca oleracea, wistar rat, ovariectomy, estrous cycle, hormones. Gynecology and obstetrics RG1-991 Reproduction QH471-489
Acceso en línea:	https://doaj.org/article/5759e703770244e7a0e0b04f9869fda2
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spelling	oai:doaj.org-article:5759e703770244e7a0e0b04f9869fda22021-11-16T07:24:40ZPortulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study2476-41082476-377210.18502/ijrm.v19i10.9822https://doaj.org/article/5759e703770244e7a0e0b04f9869fda22021-10-01T00:00:00Zhttps://doi.org/10.18502/ijrm.v19i10.9822https://doaj.org/toc/2476-4108https://doaj.org/toc/2476-3772Abstract Background: Portulaca oleracea (PO) is a widely known plant utilized for its medicinal attributes in the treatment of different illnesses. Objective: To investigate the effect of methanolic extract of PO (MEPO) on ovariectomy-induced reproductive toxicity in normal cyclic rats. Materials and Methods: Twenty 10-wk-old normal cyclic rats weighing 110-200 g were randomly divided into four groups (n = 5/group). Group A served as the control and received distilled water only. Group B was ovariectomized without treatment, while groups C and D were ovariectomized but treated with 400 and 800 mg/kg of MEPO, respectively, for 14 days. At the end of the experiment, body weight, serum hormonal levels, and estrous cycles were monitored across the groups. Results: Groups B, C, and D showed estrous cycle dysregulation and specific phase arrest when compared with the control. While a significant decrease in estradiol (p ≤ 0.001) and testosterone levels (p ≤ 0.001) were observed in groups B, C, and D, only groups C and D showed a significant increase in progesterone level when compared with the control (p ≤ 0.001, p = 0.01, respectively). Conclusion: The administration of 400 and 800 mg/kg MEPO is ineffective in ameliorating estrous cycle disruption and hormonal changes seen in ovariectomized normal cyclic adult Wistar rats.Izuchukwu Azuka OkaforUchenna Somtochukwu OkaforVictor NdukweShahid Sadoughi University of Medical Sciencesarticleportulaca oleracea, wistar rat, ovariectomy, estrous cycle, hormones.Gynecology and obstetricsRG1-991ReproductionQH471-489ENInternational Journal of Reproductive BioMedicine, Vol 19, Iss 10, Pp 899-908 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	portulaca oleracea, wistar rat, ovariectomy, estrous cycle, hormones. Gynecology and obstetrics RG1-991 Reproduction QH471-489
spellingShingle	portulaca oleracea, wistar rat, ovariectomy, estrous cycle, hormones. Gynecology and obstetrics RG1-991 Reproduction QH471-489 Izuchukwu Azuka Okafor Uchenna Somtochukwu Okafor Victor Ndukwe Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study
description	Abstract Background: Portulaca oleracea (PO) is a widely known plant utilized for its medicinal attributes in the treatment of different illnesses. Objective: To investigate the effect of methanolic extract of PO (MEPO) on ovariectomy-induced reproductive toxicity in normal cyclic rats. Materials and Methods: Twenty 10-wk-old normal cyclic rats weighing 110-200 g were randomly divided into four groups (n = 5/group). Group A served as the control and received distilled water only. Group B was ovariectomized without treatment, while groups C and D were ovariectomized but treated with 400 and 800 mg/kg of MEPO, respectively, for 14 days. At the end of the experiment, body weight, serum hormonal levels, and estrous cycles were monitored across the groups. Results: Groups B, C, and D showed estrous cycle dysregulation and specific phase arrest when compared with the control. While a significant decrease in estradiol (p ≤ 0.001) and testosterone levels (p ≤ 0.001) were observed in groups B, C, and D, only groups C and D showed a significant increase in progesterone level when compared with the control (p ≤ 0.001, p = 0.01, respectively). Conclusion: The administration of 400 and 800 mg/kg MEPO is ineffective in ameliorating estrous cycle disruption and hormonal changes seen in ovariectomized normal cyclic adult Wistar rats.
format	article
author	Izuchukwu Azuka Okafor Uchenna Somtochukwu Okafor Victor Ndukwe
author_facet	Izuchukwu Azuka Okafor Uchenna Somtochukwu Okafor Victor Ndukwe
author_sort	Izuchukwu Azuka Okafor
title	Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study
title_short	Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study
title_full	Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study
title_fullStr	Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study
title_full_unstemmed	Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study
title_sort	portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: an experimental study
publisher	Shahid Sadoughi University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/5759e703770244e7a0e0b04f9869fda2
work_keys_str_mv	AT izuchukwuazukaokafor portulacaoleraceashowsnoameliorativepotentialonovariectomyinducedhormonalandestrouscycledysregulationinnormalcyclicratsanexperimentalstudy AT uchennasomtochukwuokafor portulacaoleraceashowsnoameliorativepotentialonovariectomyinducedhormonalandestrouscycledysregulationinnormalcyclicratsanexperimentalstudy AT victorndukwe portulacaoleraceashowsnoameliorativepotentialonovariectomyinducedhormonalandestrouscycledysregulationinnormalcyclicratsanexperimentalstudy
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Portulaca oleracea shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study

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