Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease

Abstract Blood circulating microRNAs (miRNAs) are proposed to be promising biomarkers for many neurodegenerative disorders, including Parkinson’s disease (PD). However, there is a lack of identified differentially expressed miRNAs in PD from different studies. The aim of this study was to evaluate m...

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Autores principales:	Qihua Chen, Na Deng, Ke Lu, Qiao Liao, Xiaoyan Long, Deming Gou, Fangfang Bi, Jinxia Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/575bb908b010497b9e21bb89ae948dba
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spelling	oai:doaj.org-article:575bb908b010497b9e21bb89ae948dba2021-12-02T16:06:41ZElevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease10.1038/s41598-021-94734-z2045-2322https://doaj.org/article/575bb908b010497b9e21bb89ae948dba2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94734-zhttps://doaj.org/toc/2045-2322Abstract Blood circulating microRNAs (miRNAs) are proposed to be promising biomarkers for many neurodegenerative disorders, including Parkinson’s disease (PD). However, there is a lack of identified differentially expressed miRNAs in PD from different studies. The aim of this study was to evaluate miRNAs expression in PD. We measured plasma circulating miRNA expression in three independent sets with a total of 151 PD patients, 21 multiple system atrophy (MSA) patients and 138 healthy controls using high-throughput RT-PCR. We identified that elevated miR-133b and miR-221-3p discriminated early-stage PD from controls with 94.4% sensitivity and 91.1% specificity. Elevated miR-133b and miR-221-3p distinguished PD from controls with 84.8% sensitivity and 88.9% specificity. In addition, miR-4454 distinguished PD from MSA with 57.1% sensitivity and 82.6% specificity. Hence, elevated miR-133b and miR-221-3p potentially represent good biomarkers for early PD, and a combination of miR-133b, miR-221-3p and miR-4454 has the potential to serve as a non-invasive biomarker for PD diagnosis.Qihua ChenNa DengKe LuQiao LiaoXiaoyan LongDeming GouFangfang BiJinxia ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qihua Chen Na Deng Ke Lu Qiao Liao Xiaoyan Long Deming Gou Fangfang Bi Jinxia Zhou Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease
description	Abstract Blood circulating microRNAs (miRNAs) are proposed to be promising biomarkers for many neurodegenerative disorders, including Parkinson’s disease (PD). However, there is a lack of identified differentially expressed miRNAs in PD from different studies. The aim of this study was to evaluate miRNAs expression in PD. We measured plasma circulating miRNA expression in three independent sets with a total of 151 PD patients, 21 multiple system atrophy (MSA) patients and 138 healthy controls using high-throughput RT-PCR. We identified that elevated miR-133b and miR-221-3p discriminated early-stage PD from controls with 94.4% sensitivity and 91.1% specificity. Elevated miR-133b and miR-221-3p distinguished PD from controls with 84.8% sensitivity and 88.9% specificity. In addition, miR-4454 distinguished PD from MSA with 57.1% sensitivity and 82.6% specificity. Hence, elevated miR-133b and miR-221-3p potentially represent good biomarkers for early PD, and a combination of miR-133b, miR-221-3p and miR-4454 has the potential to serve as a non-invasive biomarker for PD diagnosis.
format	article
author	Qihua Chen Na Deng Ke Lu Qiao Liao Xiaoyan Long Deming Gou Fangfang Bi Jinxia Zhou
author_facet	Qihua Chen Na Deng Ke Lu Qiao Liao Xiaoyan Long Deming Gou Fangfang Bi Jinxia Zhou
author_sort	Qihua Chen
title	Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease
title_short	Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease
title_full	Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease
title_fullStr	Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease
title_full_unstemmed	Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease
title_sort	elevated plasma mir-133b and mir-221-3p as biomarkers for early parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/575bb908b010497b9e21bb89ae948dba
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Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease

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