Placenta-derived exosomes: potential biomarkers of preeclampsia

Preenan Pillay,1,2 Kogi Moodley,1 Jagidesa Moodley,3 Irene Mackraj3 1Discipline of Human Physiology, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 2Pearson Institute of Higher Education, Midrand, South Afr...

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Autores principales:	Pillay P, Moodley K, Moodley J, Mackraj I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Placental-derived exosomes Preeclampsia Biomarkers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/575f90e13154402580ecfd5e7446d7b6
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spelling	oai:doaj.org-article:575f90e13154402580ecfd5e7446d7b62021-12-02T07:28:30ZPlacenta-derived exosomes: potential biomarkers of preeclampsia1178-2013https://doaj.org/article/575f90e13154402580ecfd5e7446d7b62017-10-01T00:00:00Zhttps://www.dovepress.com/placenta-derived-exosomes-potential-biomarkers-of-preeclampsia-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Preenan Pillay,1,2 Kogi Moodley,1 Jagidesa Moodley,3 Irene Mackraj3 1Discipline of Human Physiology, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 2Pearson Institute of Higher Education, Midrand, South Africa; 3Women’s Health and HIV Research Group, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa Abstract: Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal–fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia. Keywords: placenta-derived exosomes, preeclampsia, biomarkersPillay PMoodley KMoodley JMackraj IDove Medical PressarticlePlacental-derived exosomesPreeclampsiaBiomarkersMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8009-8023 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Placental-derived exosomes Preeclampsia Biomarkers Medicine (General) R5-920
spellingShingle	Placental-derived exosomes Preeclampsia Biomarkers Medicine (General) R5-920 Pillay P Moodley K Moodley J Mackraj I Placenta-derived exosomes: potential biomarkers of preeclampsia
description	Preenan Pillay,1,2 Kogi Moodley,1 Jagidesa Moodley,3 Irene Mackraj3 1Discipline of Human Physiology, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; 2Pearson Institute of Higher Education, Midrand, South Africa; 3Women’s Health and HIV Research Group, Nelson R Mandela School of Medicine, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa Abstract: Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies. This occurs as a result of the specific placenta-derived exosomal molecular cargo, which may be involved in normal pregnancy-associated immunological events, such as the maintenance of maternal–fetal tolerance. This review provides perspectives on placenta-derived exosomes as possible biomarkers for the diagnosis/prognosis of preeclampsia. Using keywords, online databases were searched to identify relevant publications to review the potential use of placenta-derived exosomes as biomarkers of preeclampsia. Keywords: placenta-derived exosomes, preeclampsia, biomarkers
format	article
author	Pillay P Moodley K Moodley J Mackraj I
author_facet	Pillay P Moodley K Moodley J Mackraj I
author_sort	Pillay P
title	Placenta-derived exosomes: potential biomarkers of preeclampsia
title_short	Placenta-derived exosomes: potential biomarkers of preeclampsia
title_full	Placenta-derived exosomes: potential biomarkers of preeclampsia
title_fullStr	Placenta-derived exosomes: potential biomarkers of preeclampsia
title_full_unstemmed	Placenta-derived exosomes: potential biomarkers of preeclampsia
title_sort	placenta-derived exosomes: potential biomarkers of preeclampsia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/575f90e13154402580ecfd5e7446d7b6
work_keys_str_mv	AT pillayp placentaderivedexosomespotentialbiomarkersofpreeclampsia AT moodleyk placentaderivedexosomespotentialbiomarkersofpreeclampsia AT moodleyj placentaderivedexosomespotentialbiomarkersofpreeclampsia AT mackraji placentaderivedexosomespotentialbiomarkersofpreeclampsia
_version_	1718399402827055104

Placenta-derived exosomes: potential biomarkers of preeclampsia

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