Heterochronic faecal transplantation boosts gut germinal centres in aged mice

Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directional...

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Autores principales:	Marisa Stebegg, Alyssa Silva-Cayetano, Silvia Innocentin, Timothy P. Jenkins, Cinzia Cantacessi, Colin Gilbert, Michelle A. Linterman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57607b62c778463fae0cd13bdc1ae69b
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spelling	oai:doaj.org-article:57607b62c778463fae0cd13bdc1ae69b2021-12-02T14:39:36ZHeterochronic faecal transplantation boosts gut germinal centres in aged mice10.1038/s41467-019-10430-72041-1723https://doaj.org/article/57607b62c778463fae0cd13bdc1ae69b2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10430-7https://doaj.org/toc/2041-1723Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directionality.Marisa StebeggAlyssa Silva-CayetanoSilvia InnocentinTimothy P. JenkinsCinzia CantacessiColin GilbertMichelle A. LintermanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marisa Stebegg Alyssa Silva-Cayetano Silvia Innocentin Timothy P. Jenkins Cinzia Cantacessi Colin Gilbert Michelle A. Linterman Heterochronic faecal transplantation boosts gut germinal centres in aged mice
description	Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directionality.
format	article
author	Marisa Stebegg Alyssa Silva-Cayetano Silvia Innocentin Timothy P. Jenkins Cinzia Cantacessi Colin Gilbert Michelle A. Linterman
author_facet	Marisa Stebegg Alyssa Silva-Cayetano Silvia Innocentin Timothy P. Jenkins Cinzia Cantacessi Colin Gilbert Michelle A. Linterman
author_sort	Marisa Stebegg
title	Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_short	Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_full	Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_fullStr	Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_full_unstemmed	Heterochronic faecal transplantation boosts gut germinal centres in aged mice
title_sort	heterochronic faecal transplantation boosts gut germinal centres in aged mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/57607b62c778463fae0cd13bdc1ae69b
work_keys_str_mv	AT marisastebegg heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice AT alyssasilvacayetano heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice AT silviainnocentin heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice AT timothypjenkins heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice AT cinziacantacessi heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice AT colingilbert heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice AT michellealinterman heterochronicfaecaltransplantationboostsgutgerminalcentresinagedmice
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Heterochronic faecal transplantation boosts gut germinal centres in aged mice

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