Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates

Some bacterial lineages appear to be pre-disposed to evolving antibiotic resistance. Here, the authors show that differential expression of an efflux pump causes widespread variation in evolvability across Staphylococcus aureus isolates, and chemical inhibition of the pump prevents resistance evolut...

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Autores principales:	Andrei Papkou, Jessica Hedge, Natalia Kapel, Bernadette Young, R. Craig MacLean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57622c4011834f13aa48b1b348252284
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spelling	oai:doaj.org-article:57622c4011834f13aa48b1b3482522842021-12-02T14:53:37ZEfflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates10.1038/s41467-020-17735-y2041-1723https://doaj.org/article/57622c4011834f13aa48b1b3482522842020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17735-yhttps://doaj.org/toc/2041-1723Some bacterial lineages appear to be pre-disposed to evolving antibiotic resistance. Here, the authors show that differential expression of an efflux pump causes widespread variation in evolvability across Staphylococcus aureus isolates, and chemical inhibition of the pump prevents resistance evolution.Andrei PapkouJessica HedgeNatalia KapelBernadette YoungR. Craig MacLeanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrei Papkou Jessica Hedge Natalia Kapel Bernadette Young R. Craig MacLean Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
description	Some bacterial lineages appear to be pre-disposed to evolving antibiotic resistance. Here, the authors show that differential expression of an efflux pump causes widespread variation in evolvability across Staphylococcus aureus isolates, and chemical inhibition of the pump prevents resistance evolution.
format	article
author	Andrei Papkou Jessica Hedge Natalia Kapel Bernadette Young R. Craig MacLean
author_facet	Andrei Papkou Jessica Hedge Natalia Kapel Bernadette Young R. Craig MacLean
author_sort	Andrei Papkou
title	Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
title_short	Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
title_full	Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
title_fullStr	Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
title_full_unstemmed	Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
title_sort	efflux pump activity potentiates the evolution of antibiotic resistance across s. aureus isolates
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/57622c4011834f13aa48b1b348252284
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Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates

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