Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates

Some bacterial lineages appear to be pre-disposed to evolving antibiotic resistance. Here, the authors show that differential expression of an efflux pump causes widespread variation in evolvability across Staphylococcus aureus isolates, and chemical inhibition of the pump prevents resistance evolut...

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Autores principales: Andrei Papkou, Jessica Hedge, Natalia Kapel, Bernadette Young, R. Craig MacLean
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/57622c4011834f13aa48b1b348252284
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