A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage
Abstract Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear....
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Nature Portfolio
2017
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oai:doaj.org-article:5762e85079c946d6880ec1de12cf95c22021-12-02T15:05:46ZA high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage10.1038/s41598-017-00505-02045-2322https://doaj.org/article/5762e85079c946d6880ec1de12cf95c22017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00505-0https://doaj.org/toc/2045-2322Abstract Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear. We established a HFD model in mice treated at immature stage (mice-TIS) and mice treated at mature stage (mice-TMS). Surprisingly, we found that a HFD decreased IL1β levels and was accompanied by an increase in testosterone in mice-TIS, while the reverse results were observed in mice-TMS. In addition, a HFD caused a reduction in testis macrophages and in the expression of inflammasome-related genes and proteins in mice-TIS. Furthermore, we found that IL1β inhibited testosterone secretion through down-regulating the gene expression of P450SCC and P450c17. However, the influence on mice-TIS that were induced by a HFD was recovered by stopping the HFD. In this study, we are the first to report that a HFD impairs the reproductive system by decreasing IL1β and enhancing testosterone levels in mice-TIS, which are different from the effects in mice-TMS. This provides new ideas for the treatment of obesity-induced infertility.Jie Zhangkai LiMiao YuanJie ZhangGuizen HuangJie AoHaoze TanYanyan LiDi GongJun Lilei KangNini AnFei LiPing LinLugang HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
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Medicine R Science Q Jie Zhang kai Li Miao Yuan Jie Zhang Guizen Huang Jie Ao Haoze Tan Yanyan Li Di Gong Jun Li lei Kang Nini An Fei Li Ping Lin Lugang Huang A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage |
| description |
Abstract Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear. We established a HFD model in mice treated at immature stage (mice-TIS) and mice treated at mature stage (mice-TMS). Surprisingly, we found that a HFD decreased IL1β levels and was accompanied by an increase in testosterone in mice-TIS, while the reverse results were observed in mice-TMS. In addition, a HFD caused a reduction in testis macrophages and in the expression of inflammasome-related genes and proteins in mice-TIS. Furthermore, we found that IL1β inhibited testosterone secretion through down-regulating the gene expression of P450SCC and P450c17. However, the influence on mice-TIS that were induced by a HFD was recovered by stopping the HFD. In this study, we are the first to report that a HFD impairs the reproductive system by decreasing IL1β and enhancing testosterone levels in mice-TIS, which are different from the effects in mice-TMS. This provides new ideas for the treatment of obesity-induced infertility. |
| format |
article |
| author |
Jie Zhang kai Li Miao Yuan Jie Zhang Guizen Huang Jie Ao Haoze Tan Yanyan Li Di Gong Jun Li lei Kang Nini An Fei Li Ping Lin Lugang Huang |
| author_facet |
Jie Zhang kai Li Miao Yuan Jie Zhang Guizen Huang Jie Ao Haoze Tan Yanyan Li Di Gong Jun Li lei Kang Nini An Fei Li Ping Lin Lugang Huang |
| author_sort |
Jie Zhang |
| title |
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage |
| title_short |
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage |
| title_full |
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage |
| title_fullStr |
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage |
| title_full_unstemmed |
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage |
| title_sort |
high-fat diet impairs reproduction by decreasing the il1β level in mice treated at immature stage |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/5762e85079c946d6880ec1de12cf95c2 |
| work_keys_str_mv |
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