An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure

Abstract Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion. Recent work has identified the synapse between cochlear primary afferent neurons and sensory...

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Autores principales:	Jerome Nevoux, Mihaela Alexandru, Thomas Bellocq, Lei Tanaka, Yushi Hayashi, Takahisa Watabe, Hanae Lahlou, Kohsuke Tani, Albert S. B. Edge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5767b2943b184f829c220f9b9a787b17
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spelling	oai:doaj.org-article:5767b2943b184f829c220f9b9a787b172021-12-02T14:06:11ZAn antibody to RGMa promotes regeneration of cochlear synapses after noise exposure10.1038/s41598-021-81294-52045-2322https://doaj.org/article/5767b2943b184f829c220f9b9a787b172021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81294-5https://doaj.org/toc/2045-2322Abstract Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion. Recent work has identified the synapse between cochlear primary afferent neurons and sensory hair cells as a particularly vulnerable component of this pathway. Loss of these synapses due to noise exposure or aging results in the pathology identified as hidden hearing loss, an initial stage of cochlear dysfunction that goes undetected in standard hearing tests. We show here that repulsive axonal guidance molecule a (RGMa) acts to prevent regrowth and synaptogenesis of peripheral auditory nerve fibers with inner hair cells. Treatment of noise-exposed animals with an anti-RGMa blocking antibody regenerated inner hair cell synapses and resulted in recovery of wave-I amplitude of the auditory brainstem response, indicating effective reversal of synaptopathy.Jerome NevouxMihaela AlexandruThomas BellocqLei TanakaYushi HayashiTakahisa WatabeHanae LahlouKohsuke TaniAlbert S. B. EdgeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jerome Nevoux Mihaela Alexandru Thomas Bellocq Lei Tanaka Yushi Hayashi Takahisa Watabe Hanae Lahlou Kohsuke Tani Albert S. B. Edge An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
description	Abstract Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion. Recent work has identified the synapse between cochlear primary afferent neurons and sensory hair cells as a particularly vulnerable component of this pathway. Loss of these synapses due to noise exposure or aging results in the pathology identified as hidden hearing loss, an initial stage of cochlear dysfunction that goes undetected in standard hearing tests. We show here that repulsive axonal guidance molecule a (RGMa) acts to prevent regrowth and synaptogenesis of peripheral auditory nerve fibers with inner hair cells. Treatment of noise-exposed animals with an anti-RGMa blocking antibody regenerated inner hair cell synapses and resulted in recovery of wave-I amplitude of the auditory brainstem response, indicating effective reversal of synaptopathy.
format	article
author	Jerome Nevoux Mihaela Alexandru Thomas Bellocq Lei Tanaka Yushi Hayashi Takahisa Watabe Hanae Lahlou Kohsuke Tani Albert S. B. Edge
author_facet	Jerome Nevoux Mihaela Alexandru Thomas Bellocq Lei Tanaka Yushi Hayashi Takahisa Watabe Hanae Lahlou Kohsuke Tani Albert S. B. Edge
author_sort	Jerome Nevoux
title	An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
title_short	An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
title_full	An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
title_fullStr	An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
title_full_unstemmed	An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
title_sort	antibody to rgma promotes regeneration of cochlear synapses after noise exposure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5767b2943b184f829c220f9b9a787b17
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An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure

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