EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

The trichoplein-Aurora A pathway inhibits ciliogenesis in proliferating cells. Here the authors EGFR-mediated phosphorylation of the deubiquitinating enzyme USP8 leads to its activation, and this suppresses trichoplein degradation, allowing inhibition of ciliogenesis.

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Autores principales:	Kousuke Kasahara, Hiromasa Aoki, Tohru Kiyono, Shujie Wang, Harumi Kagiwada, Mizuki Yuge, Toshio Tanaka, Yuhei Nishimura, Akira Mizoguchi, Naoki Goshima, Masaki Inagaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5767c7f8761444a4ac49f9d343f894ad
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spelling	oai:doaj.org-article:5767c7f8761444a4ac49f9d343f894ad2021-12-02T15:33:34ZEGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase10.1038/s41467-018-03117-y2041-1723https://doaj.org/article/5767c7f8761444a4ac49f9d343f894ad2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03117-yhttps://doaj.org/toc/2041-1723The trichoplein-Aurora A pathway inhibits ciliogenesis in proliferating cells. Here the authors EGFR-mediated phosphorylation of the deubiquitinating enzyme USP8 leads to its activation, and this suppresses trichoplein degradation, allowing inhibition of ciliogenesis.Kousuke KasaharaHiromasa AokiTohru KiyonoShujie WangHarumi KagiwadaMizuki YugeToshio TanakaYuhei NishimuraAkira MizoguchiNaoki GoshimaMasaki InagakiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kousuke Kasahara Hiromasa Aoki Tohru Kiyono Shujie Wang Harumi Kagiwada Mizuki Yuge Toshio Tanaka Yuhei Nishimura Akira Mizoguchi Naoki Goshima Masaki Inagaki EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
description	The trichoplein-Aurora A pathway inhibits ciliogenesis in proliferating cells. Here the authors EGFR-mediated phosphorylation of the deubiquitinating enzyme USP8 leads to its activation, and this suppresses trichoplein degradation, allowing inhibition of ciliogenesis.
format	article
author	Kousuke Kasahara Hiromasa Aoki Tohru Kiyono Shujie Wang Harumi Kagiwada Mizuki Yuge Toshio Tanaka Yuhei Nishimura Akira Mizoguchi Naoki Goshima Masaki Inagaki
author_facet	Kousuke Kasahara Hiromasa Aoki Tohru Kiyono Shujie Wang Harumi Kagiwada Mizuki Yuge Toshio Tanaka Yuhei Nishimura Akira Mizoguchi Naoki Goshima Masaki Inagaki
author_sort	Kousuke Kasahara
title	EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
title_short	EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
title_full	EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
title_fullStr	EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
title_full_unstemmed	EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
title_sort	egf receptor kinase suppresses ciliogenesis through activation of usp8 deubiquitinase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5767c7f8761444a4ac49f9d343f894ad
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EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

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