Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice
Abstract Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and...
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Nature Portfolio
2017
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oai:doaj.org-article:5769f0bc52c44f24bcbd98c871005d1f2021-12-02T15:05:34ZCombination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice10.1038/s41598-017-04308-12045-2322https://doaj.org/article/5769f0bc52c44f24bcbd98c871005d1f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04308-1https://doaj.org/toc/2045-2322Abstract Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less. HS had increased plasma AST activity and liver type I collagen. HF caused mild liver steatosis and hepatocellular damage. HF and HSHF increased LDL-cholesterol, hepatocyte and adipocyte hypertrophy, TNF-α by macrophages and decreased lipogenesis and adiponectin in adipose tissue (AT). HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1β, VCAM-1, and ICAM-1 protein in AT. The three obesogenic diets induced obesity and metabolic dysfunction. HS was more proinflammatory than the HF and induced hepatic fibrosis. The HF was more detrimental in terms of insulin sensitivity, and it caused liver steatosis. The combination HSHF exacerbated the effects of each separately on insulin resistance and AT inflammatory state.Laureane Nunes MasiAmanda Roque MartinsAmanda Rabello CrismaCátia Lira do AmaralMariana Rodrigues DavansoTamires Duarte Afonso SerdanRoberta Dourado Cavalcante da Cunha de SáMaysa Mariana CruzMaria Isabel Cardoso Alonso-ValeRosângela Pavan TorresJorge Mancini-FilhoJoice Naiara Bertaglia PereiraMarta Maria da Silva RighettiEdson Aparecido LibertiSandro Massao HirabaraRui CuriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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Medicine R Science Q Laureane Nunes Masi Amanda Roque Martins Amanda Rabello Crisma Cátia Lira do Amaral Mariana Rodrigues Davanso Tamires Duarte Afonso Serdan Roberta Dourado Cavalcante da Cunha de Sá Maysa Mariana Cruz Maria Isabel Cardoso Alonso-Vale Rosângela Pavan Torres Jorge Mancini-Filho Joice Naiara Bertaglia Pereira Marta Maria da Silva Righetti Edson Aparecido Liberti Sandro Massao Hirabara Rui Curi Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice |
| description |
Abstract Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less. HS had increased plasma AST activity and liver type I collagen. HF caused mild liver steatosis and hepatocellular damage. HF and HSHF increased LDL-cholesterol, hepatocyte and adipocyte hypertrophy, TNF-α by macrophages and decreased lipogenesis and adiponectin in adipose tissue (AT). HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1β, VCAM-1, and ICAM-1 protein in AT. The three obesogenic diets induced obesity and metabolic dysfunction. HS was more proinflammatory than the HF and induced hepatic fibrosis. The HF was more detrimental in terms of insulin sensitivity, and it caused liver steatosis. The combination HSHF exacerbated the effects of each separately on insulin resistance and AT inflammatory state. |
| format |
article |
| author |
Laureane Nunes Masi Amanda Roque Martins Amanda Rabello Crisma Cátia Lira do Amaral Mariana Rodrigues Davanso Tamires Duarte Afonso Serdan Roberta Dourado Cavalcante da Cunha de Sá Maysa Mariana Cruz Maria Isabel Cardoso Alonso-Vale Rosângela Pavan Torres Jorge Mancini-Filho Joice Naiara Bertaglia Pereira Marta Maria da Silva Righetti Edson Aparecido Liberti Sandro Massao Hirabara Rui Curi |
| author_facet |
Laureane Nunes Masi Amanda Roque Martins Amanda Rabello Crisma Cátia Lira do Amaral Mariana Rodrigues Davanso Tamires Duarte Afonso Serdan Roberta Dourado Cavalcante da Cunha de Sá Maysa Mariana Cruz Maria Isabel Cardoso Alonso-Vale Rosângela Pavan Torres Jorge Mancini-Filho Joice Naiara Bertaglia Pereira Marta Maria da Silva Righetti Edson Aparecido Liberti Sandro Massao Hirabara Rui Curi |
| author_sort |
Laureane Nunes Masi |
| title |
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice |
| title_short |
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice |
| title_full |
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice |
| title_fullStr |
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice |
| title_full_unstemmed |
Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice |
| title_sort |
combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/5769f0bc52c44f24bcbd98c871005d1f |
| work_keys_str_mv |
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