Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate

In the current work, mesoporous magnesium carbonate (MMC) was used to suppress crystallization of the poorly soluble drug celecoxib (CXB). This resulted in both a higher dissolution rate and supersaturation of the substance in vitro as well as an increased transfer of CXB over a Caco-2 cell membrane...

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Autores principales:	Johan Gómez de la Torre, Christel Bergström, Teresa Zardán Gómez de la Torre
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesoporous materials magnesium carbonate poorly soluble drugs celecoxib Caco-2 cell membrane drug release Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/576b0e42002f47b4bc271a90057626d8
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spelling	oai:doaj.org-article:576b0e42002f47b4bc271a90057626d82021-11-11T18:23:01ZIncreasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate10.3390/molecules262163531420-3049https://doaj.org/article/576b0e42002f47b4bc271a90057626d82021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6353https://doaj.org/toc/1420-3049In the current work, mesoporous magnesium carbonate (MMC) was used to suppress crystallization of the poorly soluble drug celecoxib (CXB). This resulted in both a higher dissolution rate and supersaturation of the substance in vitro as well as an increased transfer of CXB over a Caco-2 cell membrane mimicking the membrane in the small intestine. The CXB flux over the cell membrane showed a linear behavior over the explored time period. These results indicate that MMC may be helpful in increasing the bioavailability and obtaining a continuous release of CXB, and similar substances, in vivo. Neusilin US2 was used as a reference material and showed a more rapid initial release with subsequent crystallization of the incorporated CXB in the release media. The presented results form the foundation of future development of MMC as a potential carrier for poorly soluble drugs.Johan Gómez de la TorreChristel BergströmTeresa Zardán Gómez de la TorreMDPI AGarticlemesoporous materialsmagnesium carbonatepoorly soluble drugscelecoxibCaco-2 cell membranedrug releaseOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6353, p 6353 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous materials magnesium carbonate poorly soluble drugs celecoxib Caco-2 cell membrane drug release Organic chemistry QD241-441
spellingShingle	mesoporous materials magnesium carbonate poorly soluble drugs celecoxib Caco-2 cell membrane drug release Organic chemistry QD241-441 Johan Gómez de la Torre Christel Bergström Teresa Zardán Gómez de la Torre Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
description	In the current work, mesoporous magnesium carbonate (MMC) was used to suppress crystallization of the poorly soluble drug celecoxib (CXB). This resulted in both a higher dissolution rate and supersaturation of the substance in vitro as well as an increased transfer of CXB over a Caco-2 cell membrane mimicking the membrane in the small intestine. The CXB flux over the cell membrane showed a linear behavior over the explored time period. These results indicate that MMC may be helpful in increasing the bioavailability and obtaining a continuous release of CXB, and similar substances, in vivo. Neusilin US2 was used as a reference material and showed a more rapid initial release with subsequent crystallization of the incorporated CXB in the release media. The presented results form the foundation of future development of MMC as a potential carrier for poorly soluble drugs.
format	article
author	Johan Gómez de la Torre Christel Bergström Teresa Zardán Gómez de la Torre
author_facet	Johan Gómez de la Torre Christel Bergström Teresa Zardán Gómez de la Torre
author_sort	Johan Gómez de la Torre
title	Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
title_short	Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
title_full	Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
title_fullStr	Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
title_full_unstemmed	Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
title_sort	increasing the transport of celecoxib over a simulated intestine cell membrane model using mesoporous magnesium carbonate
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/576b0e42002f47b4bc271a90057626d8
work_keys_str_mv	AT johangomezdelatorre increasingthetransportofcelecoxiboverasimulatedintestinecellmembranemodelusingmesoporousmagnesiumcarbonate AT christelbergstrom increasingthetransportofcelecoxiboverasimulatedintestinecellmembranemodelusingmesoporousmagnesiumcarbonate AT teresazardangomezdelatorre increasingthetransportofcelecoxiboverasimulatedintestinecellmembranemodelusingmesoporousmagnesiumcarbonate
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Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate

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