Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates

Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sung W. Rhee, Irina D. Pokrovskaya, Kelly K. Ball, Kenny Ling, Yajnesh Vedanaparti, Joshua Cohen, Denzel R. D. Cruz, Oliver S. Zhao, Maria A. Aronova, Guofeng Zhang, Jeffrey A. Kamykowski, Richard D. Leapman, Brian Storrie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/576b9d87891e479cb420267b55d5590f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:576b9d87891e479cb420267b55d5590f
record_format	dspace
spelling	oai:doaj.org-article:576b9d87891e479cb420267b55d5590f2021-12-02T18:02:14ZVenous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates10.1038/s42003-021-02615-y2399-3642https://doaj.org/article/576b9d87891e479cb420267b55d5590f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02615-yhttps://doaj.org/toc/2399-3642Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” paradigm of primary hemostasis.Sung W. RheeIrina D. PokrovskayaKelly K. BallKenny LingYajnesh VedanapartiJoshua CohenDenzel R. D. CruzOliver S. ZhaoMaria A. AronovaGuofeng ZhangJeffrey A. KamykowskiRichard D. LeapmanBrian StorrieNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sung W. Rhee Irina D. Pokrovskaya Kelly K. Ball Kenny Ling Yajnesh Vedanaparti Joshua Cohen Denzel R. D. Cruz Oliver S. Zhao Maria A. Aronova Guofeng Zhang Jeffrey A. Kamykowski Richard D. Leapman Brian Storrie Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
description	Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As a result, the authors propose a “Cap and Build” paradigm of primary hemostasis.
format	article
author	Sung W. Rhee Irina D. Pokrovskaya Kelly K. Ball Kenny Ling Yajnesh Vedanaparti Joshua Cohen Denzel R. D. Cruz Oliver S. Zhao Maria A. Aronova Guofeng Zhang Jeffrey A. Kamykowski Richard D. Leapman Brian Storrie
author_facet	Sung W. Rhee Irina D. Pokrovskaya Kelly K. Ball Kenny Ling Yajnesh Vedanaparti Joshua Cohen Denzel R. D. Cruz Oliver S. Zhao Maria A. Aronova Guofeng Zhang Jeffrey A. Kamykowski Richard D. Leapman Brian Storrie
author_sort	Sung W. Rhee
title	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_short	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_full	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_fullStr	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_full_unstemmed	Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
title_sort	venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/576b9d87891e479cb420267b55d5590f
work_keys_str_mv	AT sungwrhee venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT irinadpokrovskaya venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT kellykball venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT kennyling venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT yajneshvedanaparti venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT joshuacohen venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT denzelrdcruz venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT oliverszhao venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT mariaaaronova venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT guofengzhang venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT jeffreyakamykowski venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT richarddleapman venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates AT brianstorrie venouspuncturewoundhemostasisresultsinavaultedthrombusstructuredbylocallynucleatedplateletaggregates
_version_	1718378927788916736

Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates

Ejemplares similares