Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock

(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational stu...

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Autores principales:	Osamu Nomura, Takateru Ihara, Yoshihiko Morikawa, Hiroshi Sakakibara, Yuho Horikoshi, Nobuaki Inoue
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sepsis infants 1-h bundle tachycardia Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5771e099727240df8190672ff4416838
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spelling	oai:doaj.org-article:5771e099727240df8190672ff44168382021-11-25T16:25:01ZPredictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock10.3390/antibiotics101114142079-6382https://doaj.org/article/5771e099727240df8190672ff44168382021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1414https://doaj.org/toc/2079-6382(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00–1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management.Osamu NomuraTakateru IharaYoshihiko MorikawaHiroshi SakakibaraYuho HorikoshiNobuaki InoueMDPI AGarticlesepsisinfants1-h bundletachycardiaTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1414, p 1414 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sepsis infants 1-h bundle tachycardia Therapeutics. Pharmacology RM1-950
spellingShingle	sepsis infants 1-h bundle tachycardia Therapeutics. Pharmacology RM1-950 Osamu Nomura Takateru Ihara Yoshihiko Morikawa Hiroshi Sakakibara Yuho Horikoshi Nobuaki Inoue Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
description	(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00–1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management.
format	article
author	Osamu Nomura Takateru Ihara Yoshihiko Morikawa Hiroshi Sakakibara Yuho Horikoshi Nobuaki Inoue
author_facet	Osamu Nomura Takateru Ihara Yoshihiko Morikawa Hiroshi Sakakibara Yuho Horikoshi Nobuaki Inoue
author_sort	Osamu Nomura
title	Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_short	Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_full	Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_fullStr	Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_full_unstemmed	Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_sort	predictor of early administration of antibiotics and a volume resuscitation for young infants with septic shock
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5771e099727240df8190672ff4416838
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Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock

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