Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.

Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and upt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michele P Andrasik, Gail B Broder, Stephaun E Wallace, Richa Chaturvedi, Nelson L Michael, Sally Bock, Chris Beyrer, Linda Oseso, Jasmin Aina, Jonathan Lucas, David R Wilson, James G Kublin, George A Mensah
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57720dfe13964ec8893afe5abee4dd66
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:57720dfe13964ec8893afe5abee4dd66
record_format	dspace
spelling	oai:doaj.org-article:57720dfe13964ec8893afe5abee4dd662021-12-02T20:07:50ZIncreasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.1932-620310.1371/journal.pone.0258858https://doaj.org/article/57720dfe13964ec8893afe5abee4dd662021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258858https://doaj.org/toc/1932-6203Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and uptake of future approved products. Recent data highlight the relative absence of BIPOC communities in vaccine clinical trials. Intentional and effective community engagement methods are needed to improve BIPOC inclusion. We describe the methods utilized for the successful enrollment of BIPOC participants in the U.S. Government (USG)-funded COVID-19 Prevention Network (CoVPN)-sponsored vaccine efficacy trials and analyze the demographic and enrollment data across the efficacy trials to inform future efforts to ensure inclusive participation. Across the four USG-funded COVID-19 vaccine clinical trials for which data are available, 47% of participants enrolled at CoVPN sites in the US were BIPOC. White enrollment outpaced enrollment of BIPOC participants throughout the accrual period, requiring the implementation of strategies to increase diverse and inclusive enrollment. Trials opening later benefitted considerably from strengthened community engagement efforts, and greater and more diverse volunteer registry records. Despite robust fiscal resources and a longstanding collaborative and collective effort, enrollment of White persons outpaced that of BIPOC communities. With appropriate resources, commitment and community engagement expertise, the equitable enrollment of BIPOC individuals can be achieved. To ensure this goal, intentional efforts are needed, including an emphasis on diversity of enrollment in clinical trials, establishment of enrollment goals, ongoing robust community engagement, conducting population-specific trials, and research to inform best practices.Michele P AndrasikGail B BroderStephaun E WallaceRicha ChaturvediNelson L MichaelSally BockChris BeyrerLinda OsesoJasmin AinaJonathan LucasDavid R WilsonJames G KublinGeorge A MensahPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258858 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michele P Andrasik Gail B Broder Stephaun E Wallace Richa Chaturvedi Nelson L Michael Sally Bock Chris Beyrer Linda Oseso Jasmin Aina Jonathan Lucas David R Wilson James G Kublin George A Mensah Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
description	Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and uptake of future approved products. Recent data highlight the relative absence of BIPOC communities in vaccine clinical trials. Intentional and effective community engagement methods are needed to improve BIPOC inclusion. We describe the methods utilized for the successful enrollment of BIPOC participants in the U.S. Government (USG)-funded COVID-19 Prevention Network (CoVPN)-sponsored vaccine efficacy trials and analyze the demographic and enrollment data across the efficacy trials to inform future efforts to ensure inclusive participation. Across the four USG-funded COVID-19 vaccine clinical trials for which data are available, 47% of participants enrolled at CoVPN sites in the US were BIPOC. White enrollment outpaced enrollment of BIPOC participants throughout the accrual period, requiring the implementation of strategies to increase diverse and inclusive enrollment. Trials opening later benefitted considerably from strengthened community engagement efforts, and greater and more diverse volunteer registry records. Despite robust fiscal resources and a longstanding collaborative and collective effort, enrollment of White persons outpaced that of BIPOC communities. With appropriate resources, commitment and community engagement expertise, the equitable enrollment of BIPOC individuals can be achieved. To ensure this goal, intentional efforts are needed, including an emphasis on diversity of enrollment in clinical trials, establishment of enrollment goals, ongoing robust community engagement, conducting population-specific trials, and research to inform best practices.
format	article
author	Michele P Andrasik Gail B Broder Stephaun E Wallace Richa Chaturvedi Nelson L Michael Sally Bock Chris Beyrer Linda Oseso Jasmin Aina Jonathan Lucas David R Wilson James G Kublin George A Mensah
author_facet	Michele P Andrasik Gail B Broder Stephaun E Wallace Richa Chaturvedi Nelson L Michael Sally Bock Chris Beyrer Linda Oseso Jasmin Aina Jonathan Lucas David R Wilson James G Kublin George A Mensah
author_sort	Michele P Andrasik
title	Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
title_short	Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
title_full	Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
title_fullStr	Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
title_full_unstemmed	Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
title_sort	increasing black, indigenous and people of color participation in clinical trials through community engagement and recruitment goal establishment.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/57720dfe13964ec8893afe5abee4dd66
work_keys_str_mv	AT michelepandrasik increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT gailbbroder increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT stephaunewallace increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT richachaturvedi increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT nelsonlmichael increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT sallybock increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT chrisbeyrer increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT lindaoseso increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT jasminaina increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT jonathanlucas increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT davidrwilson increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT jamesgkublin increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment AT georgeamensah increasingblackindigenousandpeopleofcolorparticipationinclinicaltrialsthroughcommunityengagementandrecruitmentgoalestablishment
_version_	1718375240644427776

Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.

Ejemplares similares