Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy

Maternal diabetes can induce neural tube defects (NTD). Here, the authors show that in mice, deletion ofPrkca(encoding protein kinase C-alpha) restores autophagy, via suppression of miR-129-2 and reversal of reduced peroxisome proliferator-activated receptor c coactivator 1alpha, so reducing NTDs.

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Autores principales: Fang Wang, Cheng Xu, E. Albert Reece, Xuezheng Li, Yanqing Wu, Christopher Harman, Jingwen Yu, Daoyin Dong, Cheng Wang, Penghua Yang, Jianxiang Zhong, Peixin Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/57742b0f8773406b8f7837912669c9dc
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spelling oai:doaj.org-article:57742b0f8773406b8f7837912669c9dc2021-12-02T14:40:38ZProtein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy10.1038/ncomms151822041-1723https://doaj.org/article/57742b0f8773406b8f7837912669c9dc2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15182https://doaj.org/toc/2041-1723Maternal diabetes can induce neural tube defects (NTD). Here, the authors show that in mice, deletion ofPrkca(encoding protein kinase C-alpha) restores autophagy, via suppression of miR-129-2 and reversal of reduced peroxisome proliferator-activated receptor c coactivator 1alpha, so reducing NTDs.Fang WangCheng XuE. Albert ReeceXuezheng LiYanqing WuChristopher HarmanJingwen YuDaoyin DongCheng WangPenghua YangJianxiang ZhongPeixin YangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fang Wang
Cheng Xu
E. Albert Reece
Xuezheng Li
Yanqing Wu
Christopher Harman
Jingwen Yu
Daoyin Dong
Cheng Wang
Penghua Yang
Jianxiang Zhong
Peixin Yang
Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
description Maternal diabetes can induce neural tube defects (NTD). Here, the authors show that in mice, deletion ofPrkca(encoding protein kinase C-alpha) restores autophagy, via suppression of miR-129-2 and reversal of reduced peroxisome proliferator-activated receptor c coactivator 1alpha, so reducing NTDs.
format article
author Fang Wang
Cheng Xu
E. Albert Reece
Xuezheng Li
Yanqing Wu
Christopher Harman
Jingwen Yu
Daoyin Dong
Cheng Wang
Penghua Yang
Jianxiang Zhong
Peixin Yang
author_facet Fang Wang
Cheng Xu
E. Albert Reece
Xuezheng Li
Yanqing Wu
Christopher Harman
Jingwen Yu
Daoyin Dong
Cheng Wang
Penghua Yang
Jianxiang Zhong
Peixin Yang
author_sort Fang Wang
title Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
title_short Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
title_full Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
title_fullStr Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
title_full_unstemmed Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
title_sort protein kinase c-alpha suppresses autophagy and induces neural tube defects via mir-129-2 in diabetic pregnancy
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/57742b0f8773406b8f7837912669c9dc
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