Mutations in <italic toggle="yes">TAC1B</italic>: a Novel Genetic Determinant of Clinical Fluconazole Resistance in <named-content content-type="genus-species">Candida auris</named-content>

Mutations in <italic toggle="yes">TAC1B</italic>: a Novel Genetic Determinant of Clinical Fluconazole Resistance in <named-content content-type="genus-species">Candida auris</named-content>

ABSTRACT Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms underpin this fluconazole resistance...

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Autores principales: Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Candida
triazole
resistance
efflux
CRISPR
WGS
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/57743729eb0c454497ebc0dcd700562d
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