Modeling Influenza Antigenic Shift and Drift with LEGO Bricks

The concepts of antigenic shift and drift could be found in almost every microbiology and virology syllabus, usually taught in the context of Influenza virus biology. They are central to understanding viral diversity and evolution and have direct application to anti-flu vaccine design and effectiven...

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Autor principal:	Boriana Marintcheva
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Special aspects of education LC8-6691 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/57787bfcfaa44945a0403d9788a8a31b
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spelling	oai:doaj.org-article:57787bfcfaa44945a0403d9788a8a31b2021-11-15T15:03:45ZModeling Influenza Antigenic Shift and Drift with LEGO Bricks10.1128/jmbe.v17i2.10961935-78851935-7877https://doaj.org/article/57787bfcfaa44945a0403d9788a8a31b2016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/jmbe.v17i2.1096https://doaj.org/toc/1935-7877https://doaj.org/toc/1935-7885The concepts of antigenic shift and drift could be found in almost every microbiology and virology syllabus, usually taught in the context of Influenza virus biology. They are central to understanding viral diversity and evolution and have direct application to anti-flu vaccine design and effectiveness. To aid student understanding of the concepts, I have developed an exercise to visualize the mechanistic aspects of antigenic shift and drift using LEGO bricks. This hands-on/minds-on exercise asks students to replicate viruses taking into account the error-prone nature of Influenza RNA polymerase and to package model virions from a host cell infected with two different Influenza strains, while keeping track of the level of diversity of newly propagated viral particles. The exercise can be executed in any type of classroom for about 10 minutes and if desired, extended to emphasize quantitative skills, molecular biology concepts, or to trigger discussion of key issues in vaccine design.Boriana MarintchevaAmerican Society for MicrobiologyarticleSpecial aspects of educationLC8-6691Biology (General)QH301-705.5ENJournal of Microbiology & Biology Education, Vol 17, Iss 2, Pp 300-301 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Special aspects of education LC8-6691 Biology (General) QH301-705.5
spellingShingle	Special aspects of education LC8-6691 Biology (General) QH301-705.5 Boriana Marintcheva Modeling Influenza Antigenic Shift and Drift with LEGO Bricks
description	The concepts of antigenic shift and drift could be found in almost every microbiology and virology syllabus, usually taught in the context of Influenza virus biology. They are central to understanding viral diversity and evolution and have direct application to anti-flu vaccine design and effectiveness. To aid student understanding of the concepts, I have developed an exercise to visualize the mechanistic aspects of antigenic shift and drift using LEGO bricks. This hands-on/minds-on exercise asks students to replicate viruses taking into account the error-prone nature of Influenza RNA polymerase and to package model virions from a host cell infected with two different Influenza strains, while keeping track of the level of diversity of newly propagated viral particles. The exercise can be executed in any type of classroom for about 10 minutes and if desired, extended to emphasize quantitative skills, molecular biology concepts, or to trigger discussion of key issues in vaccine design.
format	article
author	Boriana Marintcheva
author_facet	Boriana Marintcheva
author_sort	Boriana Marintcheva
title	Modeling Influenza Antigenic Shift and Drift with LEGO Bricks
title_short	Modeling Influenza Antigenic Shift and Drift with LEGO Bricks
title_full	Modeling Influenza Antigenic Shift and Drift with LEGO Bricks
title_fullStr	Modeling Influenza Antigenic Shift and Drift with LEGO Bricks
title_full_unstemmed	Modeling Influenza Antigenic Shift and Drift with LEGO Bricks
title_sort	modeling influenza antigenic shift and drift with lego bricks
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/57787bfcfaa44945a0403d9788a8a31b
work_keys_str_mv	AT borianamarintcheva modelinginfluenzaantigenicshiftanddriftwithlegobricks
_version_	1718428312646189056

Modeling Influenza Antigenic Shift and Drift with LEGO Bricks

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