Depression-related weight change and incident diabetes in a community sample

Abstract This cohort study aimed to compare the incidence of type 2 diabetes in adults with depression-related weight gain, depression-related weight loss, depression with no weight change, and no depression. The study sample included 59,315 community-dwelling adults in Ontario, Canada. Depression-r...

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Autores principales:	Eva Graham, Tristan Watson, Sonya S. Deschênes, Kristian B. Filion, Mélanie Henderson, Sam Harper, Laura C. Rosella, Norbert Schmitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/577aa0f055a84bf89a4435e98904ae2e
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spelling	oai:doaj.org-article:577aa0f055a84bf89a4435e98904ae2e2021-12-02T18:18:33ZDepression-related weight change and incident diabetes in a community sample10.1038/s41598-021-92963-w2045-2322https://doaj.org/article/577aa0f055a84bf89a4435e98904ae2e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92963-whttps://doaj.org/toc/2045-2322Abstract This cohort study aimed to compare the incidence of type 2 diabetes in adults with depression-related weight gain, depression-related weight loss, depression with no weight change, and no depression. The study sample included 59,315 community-dwelling adults in Ontario, Canada. Depression-related weight change in the past 12 months was measured using the Composite International Diagnostic Interview—Short Form. Participants were followed for up to 20 years using administrative health data. Cox proportional hazards models compared the incidence of type 2 diabetes in adults with depression-related weight change and in adults with no depression. Adults with depression-related weight gain had an increased risk of type 2 diabetes compared to adults no depression (HR 1.70, 95% CI 1.32–2.20), adults with depression-related weight loss (HR 1.62, 95% CI 1.09–2.42), and adults with depression with no weight change (HR 1.39, 95% CI 1.03–1.86). Adults with depression with no weight change also had an increased risk of type 2 diabetes compared to those with no depression (HR 1.23, 95% CI 1.04–1.45). Associations were stronger among women and persisted after adjusting for attained overweight and obesity. Identifying symptoms of weight change in depression may aid in identifying adults at higher risk of type 2 diabetes and in developing tailored prevention strategies.Eva GrahamTristan WatsonSonya S. DeschênesKristian B. FilionMélanie HendersonSam HarperLaura C. RosellaNorbert SchmitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Graham Tristan Watson Sonya S. Deschênes Kristian B. Filion Mélanie Henderson Sam Harper Laura C. Rosella Norbert Schmitz Depression-related weight change and incident diabetes in a community sample
description	Abstract This cohort study aimed to compare the incidence of type 2 diabetes in adults with depression-related weight gain, depression-related weight loss, depression with no weight change, and no depression. The study sample included 59,315 community-dwelling adults in Ontario, Canada. Depression-related weight change in the past 12 months was measured using the Composite International Diagnostic Interview—Short Form. Participants were followed for up to 20 years using administrative health data. Cox proportional hazards models compared the incidence of type 2 diabetes in adults with depression-related weight change and in adults with no depression. Adults with depression-related weight gain had an increased risk of type 2 diabetes compared to adults no depression (HR 1.70, 95% CI 1.32–2.20), adults with depression-related weight loss (HR 1.62, 95% CI 1.09–2.42), and adults with depression with no weight change (HR 1.39, 95% CI 1.03–1.86). Adults with depression with no weight change also had an increased risk of type 2 diabetes compared to those with no depression (HR 1.23, 95% CI 1.04–1.45). Associations were stronger among women and persisted after adjusting for attained overweight and obesity. Identifying symptoms of weight change in depression may aid in identifying adults at higher risk of type 2 diabetes and in developing tailored prevention strategies.
format	article
author	Eva Graham Tristan Watson Sonya S. Deschênes Kristian B. Filion Mélanie Henderson Sam Harper Laura C. Rosella Norbert Schmitz
author_facet	Eva Graham Tristan Watson Sonya S. Deschênes Kristian B. Filion Mélanie Henderson Sam Harper Laura C. Rosella Norbert Schmitz
author_sort	Eva Graham
title	Depression-related weight change and incident diabetes in a community sample
title_short	Depression-related weight change and incident diabetes in a community sample
title_full	Depression-related weight change and incident diabetes in a community sample
title_fullStr	Depression-related weight change and incident diabetes in a community sample
title_full_unstemmed	Depression-related weight change and incident diabetes in a community sample
title_sort	depression-related weight change and incident diabetes in a community sample
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/577aa0f055a84bf89a4435e98904ae2e
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Depression-related weight change and incident diabetes in a community sample

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