Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities

Abstract When a muscle is stretched during a contraction, the resulting steady-state force is higher than the isometric force produced at a comparable sarcomere length. This phenomenon, also referred to as residual force enhancement, cannot be readily explained by the force-sarcomere length relation...

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Autores principales:	Ricarda M. Haeger, Dilson E. Rassier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/577b09f49ddf4df1ad8556ae2f6d7ab7
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spelling	oai:doaj.org-article:577b09f49ddf4df1ad8556ae2f6d7ab72021-12-02T12:33:04ZForce enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities10.1038/s41598-020-78457-12045-2322https://doaj.org/article/577b09f49ddf4df1ad8556ae2f6d7ab72020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78457-1https://doaj.org/toc/2045-2322Abstract When a muscle is stretched during a contraction, the resulting steady-state force is higher than the isometric force produced at a comparable sarcomere length. This phenomenon, also referred to as residual force enhancement, cannot be readily explained by the force-sarcomere length relation. One of the most accepted mechanisms for the residual force enhancement is the development of sarcomere length non-uniformities after an active stretch. The aim of this study was to directly investigate the effect of non-uniformities on the force-producing capabilities of isolated myofibrils after they are actively stretched. We evaluated the effect of depleting a single A-band on sarcomere length non-uniformity and residual force enhancement. We observed that sarcomere length non-uniformity was effectively increased following A-band depletion. Furthermore, isometric forces decreased, while the percent residual force enhancement increased compared to intact myofibrils (5% vs. 20%). We conclude that sarcomere length non-uniformities are partially responsible for the enhanced force production after stretch.Ricarda M. HaegerDilson E. RassierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ricarda M. Haeger Dilson E. Rassier Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities
description	Abstract When a muscle is stretched during a contraction, the resulting steady-state force is higher than the isometric force produced at a comparable sarcomere length. This phenomenon, also referred to as residual force enhancement, cannot be readily explained by the force-sarcomere length relation. One of the most accepted mechanisms for the residual force enhancement is the development of sarcomere length non-uniformities after an active stretch. The aim of this study was to directly investigate the effect of non-uniformities on the force-producing capabilities of isolated myofibrils after they are actively stretched. We evaluated the effect of depleting a single A-band on sarcomere length non-uniformity and residual force enhancement. We observed that sarcomere length non-uniformity was effectively increased following A-band depletion. Furthermore, isometric forces decreased, while the percent residual force enhancement increased compared to intact myofibrils (5% vs. 20%). We conclude that sarcomere length non-uniformities are partially responsible for the enhanced force production after stretch.
format	article
author	Ricarda M. Haeger Dilson E. Rassier
author_facet	Ricarda M. Haeger Dilson E. Rassier
author_sort	Ricarda M. Haeger
title	Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities
title_short	Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities
title_full	Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities
title_fullStr	Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities
title_full_unstemmed	Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities
title_sort	force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/577b09f49ddf4df1ad8556ae2f6d7ab7
work_keys_str_mv	AT ricardamhaeger forceenhancementafterstretchofisolatedmyofibrilsisincreasedbysarcomerelengthnonuniformities AT dilsonerassier forceenhancementafterstretchofisolatedmyofibrilsisincreasedbysarcomerelengthnonuniformities
_version_	1718393859577217024

Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities

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