Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response

cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I interferons. Although cGAS has been considered a traditi...

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Autores principales:	Yuying Ma, Xiaohui Wang, Weisheng Luo, Ji Xiao, Xiaowei Song, Yifei Wang, Hanlin Shuai, Zhe Ren, Yiliang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cGAS RNA-binding activity RNA-binding protein phase-separated condensates innate antiviral response Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/577cf92d29034ccfa068adc742c1124e
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Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response

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