Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people

Yanlu Xin,1 Yunyang Wang,1 Jingwei Chi,2 Xvhua Zhu,3 Hui Zhao,4 Shihua Zhao,1,2 Yangang Wang1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China; 2Laboratory of Thyroid Disease, Affiliated Hospital of Qingdao University, Qingdao, China; 3Department...

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Autores principales:	Xin YL, Wang Y, Chi J, Zhu X, Zhao H, Zhao S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	FFA Insulin resistance T2DM Obesity HOMA-IR Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/577e23c5e54e484b8d245dcee2143599
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spelling	oai:doaj.org-article:577e23c5e54e484b8d245dcee21435992021-12-02T06:06:43ZElevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people1178-7007https://doaj.org/article/577e23c5e54e484b8d245dcee21435992019-01-01T00:00:00Zhttps://www.dovepress.com/elevated-free-fatty-acid-level-is-associated-with-insulin-resistant-st-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yanlu Xin,1 Yunyang Wang,1 Jingwei Chi,2 Xvhua Zhu,3 Hui Zhao,4 Shihua Zhao,1,2 Yangang Wang1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China; 2Laboratory of Thyroid Disease, Affiliated Hospital of Qingdao University, Qingdao, China; 3Department of Endocrinology and Metabolism, Second People’s Hospital of Qingdao West Coast, Qingdao, China; 4Department of Endocrinology and Metabolism, Hiser Medical Center of Qingdao, Qingdao, China Background: Free fatty acids (FFAs) are associated with insulin secretion and insulin resistance. However, the associations among FFAs, obesity, and progression from a normal to a prediabetic state are unclear. Methods: Nondiabetic subjects (5,952) were divided in two groups according to their body mass index (BMI): obese subjects (BMI ≥24 kg/m2) and nonobese subjects (BMI <24 kg/m2). Clinical and multiple glucolipid metabolism data were collected. The homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) was used. HbA1c level between 5.7% and 6.4% was considered prediabetic. Nonparametric tests, one-way ANOVA, and linear correlation analysis were performed. R and SPSS 23.0 software programs were used to analyze the results. Results: A U-shaped relationship between FFAs and HOMA-IR was observed. After adjusting for potential confounders, the turning points of FFA levels in the curves were 0.54 mmol/L in the nonobese group and 0.61 mmol/L in the obese group. HOMA-IR levels decreased with increasing FFA concentrations before the turning points (regression coefficient [β]= – 0.9, P=0.0111, for the nonobese group; β=0.2, P=0.5094, for the obese group) and then increased (β=0.9, P=0.0069, for the nonobese group; β=1.5, P=0.0263 for the obese group) after the points. Additionally, our study also identified that FFAs were associated with the prediabetes status in obese individuals. Conclusion: FFA levels were associated with insulin resistance in nondiabetic subjects, and HOMA-IR in nonobese individuals was more sensitive to FFA changes. Monitoring and controlling plasma FFA levels in obese subjects is significant in decreasing insulin resistance and preventing diabetes. Keywords: FFA, insulin resistance, T2DM, obesity, HOMA-IRXin YLWang YChi JZhu XZhao HZhao SWang YDove Medical PressarticleFFAInsulin resistanceT2DMObesityHOMA-IRSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 139-147 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	FFA Insulin resistance T2DM Obesity HOMA-IR Specialties of internal medicine RC581-951
spellingShingle	FFA Insulin resistance T2DM Obesity HOMA-IR Specialties of internal medicine RC581-951 Xin YL Wang Y Chi J Zhu X Zhao H Zhao S Wang Y Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people
description	Yanlu Xin,1 Yunyang Wang,1 Jingwei Chi,2 Xvhua Zhu,3 Hui Zhao,4 Shihua Zhao,1,2 Yangang Wang1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China; 2Laboratory of Thyroid Disease, Affiliated Hospital of Qingdao University, Qingdao, China; 3Department of Endocrinology and Metabolism, Second People’s Hospital of Qingdao West Coast, Qingdao, China; 4Department of Endocrinology and Metabolism, Hiser Medical Center of Qingdao, Qingdao, China Background: Free fatty acids (FFAs) are associated with insulin secretion and insulin resistance. However, the associations among FFAs, obesity, and progression from a normal to a prediabetic state are unclear. Methods: Nondiabetic subjects (5,952) were divided in two groups according to their body mass index (BMI): obese subjects (BMI ≥24 kg/m2) and nonobese subjects (BMI <24 kg/m2). Clinical and multiple glucolipid metabolism data were collected. The homeostasis model assessment for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) was used. HbA1c level between 5.7% and 6.4% was considered prediabetic. Nonparametric tests, one-way ANOVA, and linear correlation analysis were performed. R and SPSS 23.0 software programs were used to analyze the results. Results: A U-shaped relationship between FFAs and HOMA-IR was observed. After adjusting for potential confounders, the turning points of FFA levels in the curves were 0.54 mmol/L in the nonobese group and 0.61 mmol/L in the obese group. HOMA-IR levels decreased with increasing FFA concentrations before the turning points (regression coefficient [β]= – 0.9, P=0.0111, for the nonobese group; β=0.2, P=0.5094, for the obese group) and then increased (β=0.9, P=0.0069, for the nonobese group; β=1.5, P=0.0263 for the obese group) after the points. Additionally, our study also identified that FFAs were associated with the prediabetes status in obese individuals. Conclusion: FFA levels were associated with insulin resistance in nondiabetic subjects, and HOMA-IR in nonobese individuals was more sensitive to FFA changes. Monitoring and controlling plasma FFA levels in obese subjects is significant in decreasing insulin resistance and preventing diabetes. Keywords: FFA, insulin resistance, T2DM, obesity, HOMA-IR
format	article
author	Xin YL Wang Y Chi J Zhu X Zhao H Zhao S Wang Y
author_facet	Xin YL Wang Y Chi J Zhu X Zhao H Zhao S Wang Y
author_sort	Xin YL
title	Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people
title_short	Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people
title_full	Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people
title_fullStr	Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people
title_full_unstemmed	Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people
title_sort	elevated free fatty acid level is associated with insulin-resistant state in nondiabetic chinese people
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/577e23c5e54e484b8d245dcee2143599
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_version_	1718400050956075008

Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people

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