Molecular basis of Tousled-Like Kinase 2 activation

The Tousled-like kinase (TLKs) family belongs to a distinct branch of Ser/Thr kinases that exhibit the highest levels of activity during DNA replication. Here the authors present the crystal structure of the kinase domain from human TLK2 and propose an activation model for TLK2 based on biochemical...

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Autores principales:	Gulnahar B. Mortuza, Dario Hermida, Anna-Kathrine Pedersen, Sandra Segura-Bayona, Blanca López-Méndez, Pilar Redondo, Patrick Rüther, Irina Pozdnyakova, Ana M. Garrote, Inés G. Muñoz, Marina Villamor-Payà, Cristina Jauset, Jesper V. Olsen, Travis H. Stracker, Guillermo Montoya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5782a4cbd30a44858e898e8e1633bd30
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spelling	oai:doaj.org-article:5782a4cbd30a44858e898e8e1633bd302021-12-02T16:56:36ZMolecular basis of Tousled-Like Kinase 2 activation10.1038/s41467-018-04941-y2041-1723https://doaj.org/article/5782a4cbd30a44858e898e8e1633bd302018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04941-yhttps://doaj.org/toc/2041-1723The Tousled-like kinase (TLKs) family belongs to a distinct branch of Ser/Thr kinases that exhibit the highest levels of activity during DNA replication. Here the authors present the crystal structure of the kinase domain from human TLK2 and propose an activation model for TLK2 based on biochemical and phosphoproteomics experiments.Gulnahar B. MortuzaDario HermidaAnna-Kathrine PedersenSandra Segura-BayonaBlanca López-MéndezPilar RedondoPatrick RütherIrina PozdnyakovaAna M. GarroteInés G. MuñozMarina Villamor-PayàCristina JausetJesper V. OlsenTravis H. StrackerGuillermo MontoyaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gulnahar B. Mortuza Dario Hermida Anna-Kathrine Pedersen Sandra Segura-Bayona Blanca López-Méndez Pilar Redondo Patrick Rüther Irina Pozdnyakova Ana M. Garrote Inés G. Muñoz Marina Villamor-Payà Cristina Jauset Jesper V. Olsen Travis H. Stracker Guillermo Montoya Molecular basis of Tousled-Like Kinase 2 activation
description	The Tousled-like kinase (TLKs) family belongs to a distinct branch of Ser/Thr kinases that exhibit the highest levels of activity during DNA replication. Here the authors present the crystal structure of the kinase domain from human TLK2 and propose an activation model for TLK2 based on biochemical and phosphoproteomics experiments.
format	article
author	Gulnahar B. Mortuza Dario Hermida Anna-Kathrine Pedersen Sandra Segura-Bayona Blanca López-Méndez Pilar Redondo Patrick Rüther Irina Pozdnyakova Ana M. Garrote Inés G. Muñoz Marina Villamor-Payà Cristina Jauset Jesper V. Olsen Travis H. Stracker Guillermo Montoya
author_facet	Gulnahar B. Mortuza Dario Hermida Anna-Kathrine Pedersen Sandra Segura-Bayona Blanca López-Méndez Pilar Redondo Patrick Rüther Irina Pozdnyakova Ana M. Garrote Inés G. Muñoz Marina Villamor-Payà Cristina Jauset Jesper V. Olsen Travis H. Stracker Guillermo Montoya
author_sort	Gulnahar B. Mortuza
title	Molecular basis of Tousled-Like Kinase 2 activation
title_short	Molecular basis of Tousled-Like Kinase 2 activation
title_full	Molecular basis of Tousled-Like Kinase 2 activation
title_fullStr	Molecular basis of Tousled-Like Kinase 2 activation
title_full_unstemmed	Molecular basis of Tousled-Like Kinase 2 activation
title_sort	molecular basis of tousled-like kinase 2 activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5782a4cbd30a44858e898e8e1633bd30
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Molecular basis of Tousled-Like Kinase 2 activation

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