Pregnancy, microchimerism, and the maternal grandmother.

<h4>Background</h4>A WOMAN OF REPRODUCTIVE AGE OFTEN HARBORS A SMALL NUMBER OF FOREIGN CELLS, REFERRED TO AS MICROCHIMERISM: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies. An intriguing question is wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hilary S Gammill, Kristina M Adams Waldorf, Tessa M Aydelotte, Joëlle Lucas, Wendy M Leisenring, Nathalie C Lambert, J Lee Nelson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5782b6a18cf145fe99a0076e34969ec5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5782b6a18cf145fe99a0076e34969ec5
record_format	dspace
spelling	oai:doaj.org-article:5782b6a18cf145fe99a0076e34969ec52021-11-18T06:47:02ZPregnancy, microchimerism, and the maternal grandmother.1932-620310.1371/journal.pone.0024101https://doaj.org/article/5782b6a18cf145fe99a0076e34969ec52011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21912617/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A WOMAN OF REPRODUCTIVE AGE OFTEN HARBORS A SMALL NUMBER OF FOREIGN CELLS, REFERRED TO AS MICROCHIMERISM: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies. An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the next generation (grandchildren).<h4>Methodology/principal findings</h4>Microchimerism from a woman's (i.e. proband's) own mother (mother-of-the-proband, MP) was studied in peripheral blood samples from women followed longitudinally during pregnancy who were confirmed to have uncomplicated obstetric outcomes. Women with preeclampsia were studied at the time of diagnosis and comparison made to women with healthy pregnancies matched for parity and gestational age. Participants and family members were HLA-genotyped for DRB1, DQA1, and DQB1 loci. An HLA polymorphism unique to the woman's mother was identified, and a panel of HLA-specific quantitative PCR assays was employed to identify and quantify microchimerism. Microchimerism from the MP was identified during normal, uncomplicated pregnancy, with a peak concentration in the third trimester. The likelihood of detection increased with advancing gestational age. For each advancing trimester, there was a 12.7-fold increase in the probability of detecting microchimerism relative to the prior trimester, 95% confidence intervals 3.2, 50.3, p<0.001. None of the women with preeclampsia, compared with 30% of matched healthy women, had microchimerism (p = 0.03).<h4>Conclusions/significance</h4>These results show that microchimerism from a woman's own mother is detectable in normal pregnancy and diminished in preeclampsia, supporting the previously unexplored hypothesis that MP microchimerism may be a marker reflecting healthy maternal adaptation to pregnancy.Hilary S GammillKristina M Adams WaldorfTessa M AydelotteJoëlle LucasWendy M LeisenringNathalie C LambertJ Lee NelsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e24101 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hilary S Gammill Kristina M Adams Waldorf Tessa M Aydelotte Joëlle Lucas Wendy M Leisenring Nathalie C Lambert J Lee Nelson Pregnancy, microchimerism, and the maternal grandmother.
description	<h4>Background</h4>A WOMAN OF REPRODUCTIVE AGE OFTEN HARBORS A SMALL NUMBER OF FOREIGN CELLS, REFERRED TO AS MICROCHIMERISM: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies. An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the next generation (grandchildren).<h4>Methodology/principal findings</h4>Microchimerism from a woman's (i.e. proband's) own mother (mother-of-the-proband, MP) was studied in peripheral blood samples from women followed longitudinally during pregnancy who were confirmed to have uncomplicated obstetric outcomes. Women with preeclampsia were studied at the time of diagnosis and comparison made to women with healthy pregnancies matched for parity and gestational age. Participants and family members were HLA-genotyped for DRB1, DQA1, and DQB1 loci. An HLA polymorphism unique to the woman's mother was identified, and a panel of HLA-specific quantitative PCR assays was employed to identify and quantify microchimerism. Microchimerism from the MP was identified during normal, uncomplicated pregnancy, with a peak concentration in the third trimester. The likelihood of detection increased with advancing gestational age. For each advancing trimester, there was a 12.7-fold increase in the probability of detecting microchimerism relative to the prior trimester, 95% confidence intervals 3.2, 50.3, p<0.001. None of the women with preeclampsia, compared with 30% of matched healthy women, had microchimerism (p = 0.03).<h4>Conclusions/significance</h4>These results show that microchimerism from a woman's own mother is detectable in normal pregnancy and diminished in preeclampsia, supporting the previously unexplored hypothesis that MP microchimerism may be a marker reflecting healthy maternal adaptation to pregnancy.
format	article
author	Hilary S Gammill Kristina M Adams Waldorf Tessa M Aydelotte Joëlle Lucas Wendy M Leisenring Nathalie C Lambert J Lee Nelson
author_facet	Hilary S Gammill Kristina M Adams Waldorf Tessa M Aydelotte Joëlle Lucas Wendy M Leisenring Nathalie C Lambert J Lee Nelson
author_sort	Hilary S Gammill
title	Pregnancy, microchimerism, and the maternal grandmother.
title_short	Pregnancy, microchimerism, and the maternal grandmother.
title_full	Pregnancy, microchimerism, and the maternal grandmother.
title_fullStr	Pregnancy, microchimerism, and the maternal grandmother.
title_full_unstemmed	Pregnancy, microchimerism, and the maternal grandmother.
title_sort	pregnancy, microchimerism, and the maternal grandmother.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5782b6a18cf145fe99a0076e34969ec5
work_keys_str_mv	AT hilarysgammill pregnancymicrochimerismandthematernalgrandmother AT kristinamadamswaldorf pregnancymicrochimerismandthematernalgrandmother AT tessamaydelotte pregnancymicrochimerismandthematernalgrandmother AT joellelucas pregnancymicrochimerismandthematernalgrandmother AT wendymleisenring pregnancymicrochimerismandthematernalgrandmother AT nathalieclambert pregnancymicrochimerismandthematernalgrandmother AT jleenelson pregnancymicrochimerismandthematernalgrandmother
_version_	1718424415382798336

Pregnancy, microchimerism, and the maternal grandmother.

Ejemplares similares