During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes

Abstract Background The present availability of full genome sequences of a broad range of animal species across the whole range of evolutionary history enables one to ask questions as to the distribution of genes across the chromosomes. Do newly recruited genes, as new clades emerge, distribute at r...

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Autores principales:	Wilfred D. Stein, Moshe B. Hoshen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chromosomes Gene distribution Newly-recruited genes Paralogues Phylostratigraphy Gene ages Biotechnology TP248.13-248.65 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/57830cb866eb446b8aed688b5222ae85
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spelling	oai:doaj.org-article:57830cb866eb446b8aed688b5222ae852021-11-08T10:57:31ZDuring evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes10.1186/s12864-021-08066-31471-2164https://doaj.org/article/57830cb866eb446b8aed688b5222ae852021-11-01T00:00:00Zhttps://doi.org/10.1186/s12864-021-08066-3https://doaj.org/toc/1471-2164Abstract Background The present availability of full genome sequences of a broad range of animal species across the whole range of evolutionary history enables one to ask questions as to the distribution of genes across the chromosomes. Do newly recruited genes, as new clades emerge, distribute at random or at non-random locations? Results We extracted values for the ages of the human genes and for their current chromosome locations, from published sources. A quantitative analysis showed that the distribution of newly-added genes among and within the chromosomes appears to be increasingly non-random if one observes animals along the evolutionary series from the precursors of the tetrapoda through to the great apes, whereas the oldest genes are randomly distributed. Conclusions Randomization will result from chromosome evolution, but less and less time is available for this process as evolution proceeds. Much of the bunching of recently-added genes arises from new gene formation as paralogues in gene families, near the location of genes that were recruited in the preceding phylostratum. As examples we cite the KRTAP, ZNF, OR and some minor gene families. We show that bunching can also result from the evolution of the chromosomes themselves when, as for the KRTAP genes, blocks of genes that had previously been on disparate chromosomes become linked together.Wilfred D. SteinMoshe B. HoshenBMCarticleChromosomesGene distributionNewly-recruited genesParaloguesPhylostratigraphyGene agesBiotechnologyTP248.13-248.65GeneticsQH426-470ENBMC Genomics, Vol 22, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chromosomes Gene distribution Newly-recruited genes Paralogues Phylostratigraphy Gene ages Biotechnology TP248.13-248.65 Genetics QH426-470
spellingShingle	Chromosomes Gene distribution Newly-recruited genes Paralogues Phylostratigraphy Gene ages Biotechnology TP248.13-248.65 Genetics QH426-470 Wilfred D. Stein Moshe B. Hoshen During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes
description	Abstract Background The present availability of full genome sequences of a broad range of animal species across the whole range of evolutionary history enables one to ask questions as to the distribution of genes across the chromosomes. Do newly recruited genes, as new clades emerge, distribute at random or at non-random locations? Results We extracted values for the ages of the human genes and for their current chromosome locations, from published sources. A quantitative analysis showed that the distribution of newly-added genes among and within the chromosomes appears to be increasingly non-random if one observes animals along the evolutionary series from the precursors of the tetrapoda through to the great apes, whereas the oldest genes are randomly distributed. Conclusions Randomization will result from chromosome evolution, but less and less time is available for this process as evolution proceeds. Much of the bunching of recently-added genes arises from new gene formation as paralogues in gene families, near the location of genes that were recruited in the preceding phylostratum. As examples we cite the KRTAP, ZNF, OR and some minor gene families. We show that bunching can also result from the evolution of the chromosomes themselves when, as for the KRTAP genes, blocks of genes that had previously been on disparate chromosomes become linked together.
format	article
author	Wilfred D. Stein Moshe B. Hoshen
author_facet	Wilfred D. Stein Moshe B. Hoshen
author_sort	Wilfred D. Stein
title	During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes
title_short	During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes
title_full	During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes
title_fullStr	During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes
title_full_unstemmed	During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes
title_sort	during evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes
publisher	BMC
publishDate	2021
url	https://doaj.org/article/57830cb866eb446b8aed688b5222ae85
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During evolution from the earliest tetrapoda, newly-recruited genes are increasingly paralogues of existing genes and distribute non-randomly among the chromosomes

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