Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery

Phytochemicals are plant-derived bioactive compounds, which have been widely used for therapeutic purposes. Due to the poor water-solubility, low bioavailability and non-specific targeting characteristic, diverse classes of nanocarriers are utilized for encapsulation and delivery of bio-effective ag...

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Autores principales:	Chaoxiang Chen, Jialin Wang, Mengdi Sun, Jian Li, Hui-Min David Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Cell-derived nanovesicles (CDNs) Extracellular vesicles (EVs) Natural products Nanoparticles Delivery Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/578434f27eb14ee59a138eb6fea5d128
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spelling	oai:doaj.org-article:578434f27eb14ee59a138eb6fea5d1282021-11-14T04:30:33ZToward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery0753-332210.1016/j.biopha.2021.112416https://doaj.org/article/578434f27eb14ee59a138eb6fea5d1282022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012026https://doaj.org/toc/0753-3322Phytochemicals are plant-derived bioactive compounds, which have been widely used for therapeutic purposes. Due to the poor water-solubility, low bioavailability and non-specific targeting characteristic, diverse classes of nanocarriers are utilized for encapsulation and delivery of bio-effective agents. Cell-derived nanovesicles (CDNs), known for exosomes or extracellular vesicles (EVs), are biological nanoparticles with multiple functions. Compared to the artificial counterpart, CDNs hold great potential in drug delivery given the higher stability, superior biocompatibility and the lager capability of encapsulating bioactive molecules. Here, we provide a bench-to-bedside review of CDNs-based nanoplatform, including the bio-origin, preparation, characterization and functionalization. Beyond that, the focus is laid on the therapeutic effect of CDNs-mediated drug delivery for natural products. The state-of-art development as well as some pre-clinical applications of using CDNs for disease treatment is also summarized. It is highly expected that the continuing development of CDNs-based delivery systems will further promote the clinical utilization and translation of phyto-nanomedicines.Chaoxiang ChenJialin WangMengdi SunJian LiHui-Min David WangElsevierarticleCell-derived nanovesicles (CDNs)Extracellular vesicles (EVs)Natural productsNanoparticlesDeliveryTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112416- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cell-derived nanovesicles (CDNs) Extracellular vesicles (EVs) Natural products Nanoparticles Delivery Therapeutics. Pharmacology RM1-950
spellingShingle	Cell-derived nanovesicles (CDNs) Extracellular vesicles (EVs) Natural products Nanoparticles Delivery Therapeutics. Pharmacology RM1-950 Chaoxiang Chen Jialin Wang Mengdi Sun Jian Li Hui-Min David Wang Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery
description	Phytochemicals are plant-derived bioactive compounds, which have been widely used for therapeutic purposes. Due to the poor water-solubility, low bioavailability and non-specific targeting characteristic, diverse classes of nanocarriers are utilized for encapsulation and delivery of bio-effective agents. Cell-derived nanovesicles (CDNs), known for exosomes or extracellular vesicles (EVs), are biological nanoparticles with multiple functions. Compared to the artificial counterpart, CDNs hold great potential in drug delivery given the higher stability, superior biocompatibility and the lager capability of encapsulating bioactive molecules. Here, we provide a bench-to-bedside review of CDNs-based nanoplatform, including the bio-origin, preparation, characterization and functionalization. Beyond that, the focus is laid on the therapeutic effect of CDNs-mediated drug delivery for natural products. The state-of-art development as well as some pre-clinical applications of using CDNs for disease treatment is also summarized. It is highly expected that the continuing development of CDNs-based delivery systems will further promote the clinical utilization and translation of phyto-nanomedicines.
format	article
author	Chaoxiang Chen Jialin Wang Mengdi Sun Jian Li Hui-Min David Wang
author_facet	Chaoxiang Chen Jialin Wang Mengdi Sun Jian Li Hui-Min David Wang
author_sort	Chaoxiang Chen
title	Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery
title_short	Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery
title_full	Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery
title_fullStr	Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery
title_full_unstemmed	Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery
title_sort	toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (cdns) for natural product delivery
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/578434f27eb14ee59a138eb6fea5d128
work_keys_str_mv	AT chaoxiangchen towardthenextgenerationphytonanomedicinescellderivednanovesiclescdnsfornaturalproductdelivery AT jialinwang towardthenextgenerationphytonanomedicinescellderivednanovesiclescdnsfornaturalproductdelivery AT mengdisun towardthenextgenerationphytonanomedicinescellderivednanovesiclescdnsfornaturalproductdelivery AT jianli towardthenextgenerationphytonanomedicinescellderivednanovesiclescdnsfornaturalproductdelivery AT huimindavidwang towardthenextgenerationphytonanomedicinescellderivednanovesiclescdnsfornaturalproductdelivery
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Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery

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