MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles

Bo Wu,1,2 Shu-Ting Lu,1 Kai Deng,2 Hui Yu,2 Can Cui,2 Yang Zhang,2 Ming Wu,2 Ren-Xi Zhuo,2 Hai-Bo Xu,1 Shi-Wen Huang2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Key Laboratory of Biomedical Polymers, Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, Peo...

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Autores principales:	Wu B, Lu S, Deng K, Yu H, Cui C, Zhang Y, Wu M, Zhuo RX, Xu H, Huang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	redox-sensitive folate-targeted MRI doxorubicin lipid-polymer hybrid nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5785e542b76a4b54a1355d97beefedd1
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spelling	oai:doaj.org-article:5785e542b76a4b54a1355d97beefedd12021-12-02T04:23:12ZMRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles1178-2013https://doaj.org/article/5785e542b76a4b54a1355d97beefedd12017-09-01T00:00:00Zhttps://www.dovepress.com/mri-guided-targeting-delivery-of-doxorubicin-with-reduction-responsive-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bo Wu,1,2 Shu-Ting Lu,1 Kai Deng,2 Hui Yu,2 Can Cui,2 Yang Zhang,2 Ming Wu,2 Ren-Xi Zhuo,2 Hai-Bo Xu,1 Shi-Wen Huang2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Key Laboratory of Biomedical Polymers, Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, People’s Republic of China Abstract: In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor tumor selectivity and response. Herein, we report a new kind of Gd complex and folate-coated redox-sensitive lipid-polymer hybrid nanoparticle (Gd-FLPNP) for tumor-targeted magnetic resonance imaging and therapy. Gd-FLPNPs can simultaneously accomplish diagnostic imaging, and specific targeting and controlled release of doxorubicin (DOX). They exhibit good monodispersity, excellent size stability, and a well-defined core-shell structure. Paramagnetic nanoparticles based on gadolinium-diethylenetriaminepentaacetic acid-bis-cetylamine have paramagnetic properties with an approximately two-fold enhancement in the longitudinal relaxivity compared to clinical used Magnevist. For targeted and reduction-sensitive drug delivery, Gd-FLPNPs released DOX faster and enhanced cell uptake in vitro, and exhibited better antitumor effect both in vitro and in vivo. Keywords: redox-sensitive, tumor-targeted, gadolinium, contrast agents, PLGAWu BLu SDeng KYu HCui CZhang YWu MZhuo RXXu HHuang SDove Medical Pressarticleredox-sensitivefolate-targetedMRIdoxorubicinlipid-polymer hybrid nanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6871-6882 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	redox-sensitive folate-targeted MRI doxorubicin lipid-polymer hybrid nanoparticles Medicine (General) R5-920
spellingShingle	redox-sensitive folate-targeted MRI doxorubicin lipid-polymer hybrid nanoparticles Medicine (General) R5-920 Wu B Lu S Deng K Yu H Cui C Zhang Y Wu M Zhuo RX Xu H Huang S MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
description	Bo Wu,1,2 Shu-Ting Lu,1 Kai Deng,2 Hui Yu,2 Can Cui,2 Yang Zhang,2 Ming Wu,2 Ren-Xi Zhuo,2 Hai-Bo Xu,1 Shi-Wen Huang2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Key Laboratory of Biomedical Polymers, Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, People’s Republic of China Abstract: In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor tumor selectivity and response. Herein, we report a new kind of Gd complex and folate-coated redox-sensitive lipid-polymer hybrid nanoparticle (Gd-FLPNP) for tumor-targeted magnetic resonance imaging and therapy. Gd-FLPNPs can simultaneously accomplish diagnostic imaging, and specific targeting and controlled release of doxorubicin (DOX). They exhibit good monodispersity, excellent size stability, and a well-defined core-shell structure. Paramagnetic nanoparticles based on gadolinium-diethylenetriaminepentaacetic acid-bis-cetylamine have paramagnetic properties with an approximately two-fold enhancement in the longitudinal relaxivity compared to clinical used Magnevist. For targeted and reduction-sensitive drug delivery, Gd-FLPNPs released DOX faster and enhanced cell uptake in vitro, and exhibited better antitumor effect both in vitro and in vivo. Keywords: redox-sensitive, tumor-targeted, gadolinium, contrast agents, PLGA
format	article
author	Wu B Lu S Deng K Yu H Cui C Zhang Y Wu M Zhuo RX Xu H Huang S
author_facet	Wu B Lu S Deng K Yu H Cui C Zhang Y Wu M Zhuo RX Xu H Huang S
author_sort	Wu B
title	MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
title_short	MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
title_full	MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
title_fullStr	MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
title_full_unstemmed	MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
title_sort	mri-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5785e542b76a4b54a1355d97beefedd1
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MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles

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