Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia

Sung Woo Joo,1 Woon Yoon,2 Young Tak Jo,2 Harin Kim,2 Yangsik Kim,2 Jungsun Lee2 1Medical Corps, Republic of Korea Navy 1st Fleet, Donghae, Republic of Korea; 2Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of KoreaCorrespondence: Jungsun LeeD...

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Autores principales:	Joo SW, Yoon W, Jo YT, Kim H, Kim Y, Lee J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	schizophrenia resting-state fmri executive control network auditory network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5787e73c744746cd930e601f3d64d6b1
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spelling	oai:doaj.org-article:5787e73c744746cd930e601f3d64d6b12021-12-02T13:05:44ZAberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia1178-2021https://doaj.org/article/5787e73c744746cd930e601f3d64d6b12020-06-01T00:00:00Zhttps://www.dovepress.com/aberrant-executive-control-and-auditory-networks-in-recent-onset-schiz-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Sung Woo Joo,1 Woon Yoon,2 Young Tak Jo,2 Harin Kim,2 Yangsik Kim,2 Jungsun Lee2 1Medical Corps, Republic of Korea Navy 1st Fleet, Donghae, Republic of Korea; 2Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of KoreaCorrespondence: Jungsun LeeDepartment of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, Republic of KoreaTel +82-2-3010-3422Fax +82-2-485-8381Email js_lee@amc.seoul.krPurpose: Despite a large number of resting-state functional MRI (rsfMRI) studies in schizophrenia, current evidence on the abnormalities of functional connectivity (FC) of resting-state networks shows high variability, and the findings on recent-onset schizophrenia are insufficient compared to those on chronic schizophrenia.Patients and Methods: We performed a rsfMRI in 46 patients with recent-onset schizophrenia and 22 healthy controls. Group independent component brainmap and dual regression were performed for voxel-wise comparisons between the groups. Correlation of the symptom severity, cognitive function, duration of illness, and a total antipsychotics dose with FC was evaluated with Spearman’s rho correlation.Results: The patient group had areas with a significantly decreased FC compared to that of the control group in which it existed in the left supplementary motor cortex and supramarginal gyrus (the executive control network) and the right postcentral gyrus (the auditory network). The patient group had a significant correlation of the total antipsychotics dose with the FC of the cluster in the left supplementary motor cortex in the executive control network.Conclusion: Patients with recent-onset schizophrenia have decreased FC of the executive control and auditory networks compared to healthy controls.Keywords: schizophrenia, resting-state fMRI, executive control network, auditory networkJoo SWYoon WJo YTKim HKim YLee JDove Medical Pressarticleschizophreniaresting-state fmriexecutive control networkauditory networkNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1561-1570 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia resting-state fmri executive control network auditory network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia resting-state fmri executive control network auditory network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Joo SW Yoon W Jo YT Kim H Kim Y Lee J Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia
description	Sung Woo Joo,1 Woon Yoon,2 Young Tak Jo,2 Harin Kim,2 Yangsik Kim,2 Jungsun Lee2 1Medical Corps, Republic of Korea Navy 1st Fleet, Donghae, Republic of Korea; 2Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of KoreaCorrespondence: Jungsun LeeDepartment of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, Republic of KoreaTel +82-2-3010-3422Fax +82-2-485-8381Email js_lee@amc.seoul.krPurpose: Despite a large number of resting-state functional MRI (rsfMRI) studies in schizophrenia, current evidence on the abnormalities of functional connectivity (FC) of resting-state networks shows high variability, and the findings on recent-onset schizophrenia are insufficient compared to those on chronic schizophrenia.Patients and Methods: We performed a rsfMRI in 46 patients with recent-onset schizophrenia and 22 healthy controls. Group independent component brainmap and dual regression were performed for voxel-wise comparisons between the groups. Correlation of the symptom severity, cognitive function, duration of illness, and a total antipsychotics dose with FC was evaluated with Spearman’s rho correlation.Results: The patient group had areas with a significantly decreased FC compared to that of the control group in which it existed in the left supplementary motor cortex and supramarginal gyrus (the executive control network) and the right postcentral gyrus (the auditory network). The patient group had a significant correlation of the total antipsychotics dose with the FC of the cluster in the left supplementary motor cortex in the executive control network.Conclusion: Patients with recent-onset schizophrenia have decreased FC of the executive control and auditory networks compared to healthy controls.Keywords: schizophrenia, resting-state fMRI, executive control network, auditory network
format	article
author	Joo SW Yoon W Jo YT Kim H Kim Y Lee J
author_facet	Joo SW Yoon W Jo YT Kim H Kim Y Lee J
author_sort	Joo SW
title	Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia
title_short	Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia
title_full	Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia
title_fullStr	Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia
title_full_unstemmed	Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia
title_sort	aberrant executive control and auditory networks in recent-onset schizophrenia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5787e73c744746cd930e601f3d64d6b1
work_keys_str_mv	AT joosw aberrantexecutivecontrolandauditorynetworksinrecentonsetschizophrenia AT yoonw aberrantexecutivecontrolandauditorynetworksinrecentonsetschizophrenia AT joyt aberrantexecutivecontrolandauditorynetworksinrecentonsetschizophrenia AT kimh aberrantexecutivecontrolandauditorynetworksinrecentonsetschizophrenia AT kimy aberrantexecutivecontrolandauditorynetworksinrecentonsetschizophrenia AT leej aberrantexecutivecontrolandauditorynetworksinrecentonsetschizophrenia
_version_	1718393447609532416

Aberrant Executive Control and Auditory Networks in Recent-Onset Schizophrenia

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