Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.

<h4>Background</h4>The olivary pretectal nucleus (OPN) is a small midbrain structure responsible for pupil constriction in response to eye illumination. Previous electrophysiological studies have shown that OPN neurons code light intensity levels and therefore are called luminance detect...

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Autores principales:	Hanna J Szkudlarek, Patrycja Orlowska, Marian H Lewandowski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/578c5d96ebff45ba9165b50184a29a3d
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spelling	oai:doaj.org-article:578c5d96ebff45ba9165b50184a29a3d2021-11-18T07:25:27ZLight-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.1932-620310.1371/journal.pone.0033083https://doaj.org/article/578c5d96ebff45ba9165b50184a29a3d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22427957/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The olivary pretectal nucleus (OPN) is a small midbrain structure responsible for pupil constriction in response to eye illumination. Previous electrophysiological studies have shown that OPN neurons code light intensity levels and therefore are called luminance detectors. Recently, we described an additional population of OPN neurons, characterized by a slow rhythmic pattern of action potentials in light-on conditions. Rhythmic patterns generated by these cells last for a period of approximately 2 minutes.<h4>Methodology</h4>To answer whether oscillatory OPN cells are light responsive and whether oscillatory activity depends on retinal afferents, we performed in vivo electrophysiology experiments on urethane anaesthetized Wistar rats. Extracellular recordings were combined with changes in light conditions (light-dark-light transitions), brief light stimulations of the contralateral eye (diverse illuminances) or intraocular injections of tetrodotoxin (TTX).<h4>Conclusions</h4>We found that oscillatory neurons were able to fire rhythmically in darkness and were responsive to eye illumination in a manner resembling that of luminance detectors. Their firing rate increased together with the strength of the light stimulation. In addition, during the train of light pulses, we observed two profiles of responses: oscillation-preserving and oscillation-disrupting, which occurred during low- and high-illuminance stimuli presentation respectively. Moreover, we have shown that contralateral retina inactivation eliminated oscillation and significantly reduced the firing rate of oscillatory cells. These results suggest that contralateral retinal innervation is crucial for the generation of an oscillatory pattern in addition to its role in driving responses to visual stimuli.Hanna J SzkudlarekPatrycja OrlowskaMarian H LewandowskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33083 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hanna J Szkudlarek Patrycja Orlowska Marian H Lewandowski Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.
description	<h4>Background</h4>The olivary pretectal nucleus (OPN) is a small midbrain structure responsible for pupil constriction in response to eye illumination. Previous electrophysiological studies have shown that OPN neurons code light intensity levels and therefore are called luminance detectors. Recently, we described an additional population of OPN neurons, characterized by a slow rhythmic pattern of action potentials in light-on conditions. Rhythmic patterns generated by these cells last for a period of approximately 2 minutes.<h4>Methodology</h4>To answer whether oscillatory OPN cells are light responsive and whether oscillatory activity depends on retinal afferents, we performed in vivo electrophysiology experiments on urethane anaesthetized Wistar rats. Extracellular recordings were combined with changes in light conditions (light-dark-light transitions), brief light stimulations of the contralateral eye (diverse illuminances) or intraocular injections of tetrodotoxin (TTX).<h4>Conclusions</h4>We found that oscillatory neurons were able to fire rhythmically in darkness and were responsive to eye illumination in a manner resembling that of luminance detectors. Their firing rate increased together with the strength of the light stimulation. In addition, during the train of light pulses, we observed two profiles of responses: oscillation-preserving and oscillation-disrupting, which occurred during low- and high-illuminance stimuli presentation respectively. Moreover, we have shown that contralateral retina inactivation eliminated oscillation and significantly reduced the firing rate of oscillatory cells. These results suggest that contralateral retinal innervation is crucial for the generation of an oscillatory pattern in addition to its role in driving responses to visual stimuli.
format	article
author	Hanna J Szkudlarek Patrycja Orlowska Marian H Lewandowski
author_facet	Hanna J Szkudlarek Patrycja Orlowska Marian H Lewandowski
author_sort	Hanna J Szkudlarek
title	Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.
title_short	Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.
title_full	Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.
title_fullStr	Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.
title_full_unstemmed	Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.
title_sort	light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/578c5d96ebff45ba9165b50184a29a3d
work_keys_str_mv	AT hannajszkudlarek lightinducedresponsesofslowoscillatoryneuronsoftheratolivarypretectalnucleus AT patrycjaorlowska lightinducedresponsesofslowoscillatoryneuronsoftheratolivarypretectalnucleus AT marianhlewandowski lightinducedresponsesofslowoscillatoryneuronsoftheratolivarypretectalnucleus
_version_	1718423475949928448

Light-induced responses of slow oscillatory neurons of the rat olivary pretectal nucleus.

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