Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.

Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.

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Low plasma levels of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) are associated with decreased low-density lipoprotein (LDL) cholesterol and a reduced risk of cardiovascular disease. PCSK9 binds to the epidermal growth factor-like repeat A (EGFA) domain of LDL receptors (LDLR), very low-density...

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Autores principales: Rhogerry Deshycka, Valentino Sudaryo, Nai-Jia Huang, Yushu Xie, Liyan Y Smeding, Moon Kyung Choi, Hidde L Ploegh, Harvey F Lodish, Novalia Pishesha
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/578e74400dc64fdb8e36d78c1909d017
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Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity
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