Low toxic maghemite nanoparticles for theranostic applications

Elena A Kuchma,* Peter V Zolotukhin, Anna A Belanova, Mikhail A Soldatov, Tatiana A Lastovina, Stanislav P Kubrin, Anatoliy V Nikolsky, Lidia I Mirmikova, Alexander V Soldatov* The Smart Materials Research Center, Southern Federal University of Russia, Rostov-on-Don, Russia *These authors contribu...

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Autores principales:	Kuchma EA, Zolotukhin PV, Belanova AA, Soldatov MA, Lastovina TA, Kubrin SP, Nikolsky AV, Mirmikova LI, Soldatov AV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	magnetic nanoparticles SPIONs Maghemite theranostics in oncology toxicity ROS. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/57906359fc5542bcaa69ab4641a21fe4
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spelling	oai:doaj.org-article:57906359fc5542bcaa69ab4641a21fe42021-12-02T01:32:09ZLow toxic maghemite nanoparticles for theranostic applications1178-2013https://doaj.org/article/57906359fc5542bcaa69ab4641a21fe42017-08-01T00:00:00Zhttps://www.dovepress.com/low-toxic-maghemite-nanoparticles-for-theranostic-applications-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Elena A Kuchma,* Peter V Zolotukhin, Anna A Belanova, Mikhail A Soldatov, Tatiana A Lastovina, Stanislav P Kubrin, Anatoliy V Nikolsky, Lidia I Mirmikova, Alexander V Soldatov* The Smart Materials Research Center, Southern Federal University of Russia, Rostov-on-Don, Russia *These authors contributed equally to this work Background: Iron oxide nanoparticles have numerous and versatile biological properties, ranging from direct and immediate biochemical effects to prolonged influences on tissues. Most applications have strict requirements with respect to the chemical and physical properties of such agents. Therefore, developing rational design methods of synthesis of iron oxide nanoparticles remains of vital importance in nanobiomedicine.Methods: Low toxic superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications in oncology having spherical shape and maghemite structure were produced using the fast microwave synthesis technique and were fully characterized by several complementary methods (transmission electron microscopy [TEM], X-ray diffraction [XRD], dynamic light scattering [DLS], X-ray photoelectron spectroscopy [XPS], X-ray absorption near edge structure [XANES], Mossbauer spectroscopy, and HeLa cells toxicity testing).Results: TEM showed that the majority of the obtained nanoparticles were almost spherical and did not exceed 20 nm in diameter. The averaged DLS hydrodynamic size was found to be ~33 nm, while that of nanocrystallites estimated by XRD was ~16 nm. Both XRD and XPS studies evidenced the maghemite (γ-Fe2O3) atomic and electronic structure of the synthesized nanoparticles. The XANES data analysis demonstrated the structure of the nanoparticles being similar to that of macroscopic maghemite. The Mossbauer spectroscopy revealed the γ-Fe2O3 phase of the nanoparticles and vibration magnetometry study showed that reactive oxygen species in HeLa cells are generated both in the cytoplasm and the nucleus.Conclusion: Quasispherical Fe3+ SPIONs having the maghemite structure with the average size of 16 nm obtained by using the fast microwave synthesis technique are expected to be of great value for theranostic applications in oncology and multimodal anticancer therapy. Keywords: magnetic nanoparticles, SPIONs, maghemite, theranostics in oncology, toxicity, ROSKuchma EAZolotukhin PVBelanova AASoldatov MALastovina TAKubrin SPNikolsky AVMirmikova LISoldatov AVDove Medical Pressarticlemagnetic nanoparticlesSPIONsMaghemitetheranostics in oncologytoxicityROS.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6365-6371 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic nanoparticles SPIONs Maghemite theranostics in oncology toxicity ROS. Medicine (General) R5-920
spellingShingle	magnetic nanoparticles SPIONs Maghemite theranostics in oncology toxicity ROS. Medicine (General) R5-920 Kuchma EA Zolotukhin PV Belanova AA Soldatov MA Lastovina TA Kubrin SP Nikolsky AV Mirmikova LI Soldatov AV Low toxic maghemite nanoparticles for theranostic applications
description	Elena A Kuchma,* Peter V Zolotukhin, Anna A Belanova, Mikhail A Soldatov, Tatiana A Lastovina, Stanislav P Kubrin, Anatoliy V Nikolsky, Lidia I Mirmikova, Alexander V Soldatov* The Smart Materials Research Center, Southern Federal University of Russia, Rostov-on-Don, Russia *These authors contributed equally to this work Background: Iron oxide nanoparticles have numerous and versatile biological properties, ranging from direct and immediate biochemical effects to prolonged influences on tissues. Most applications have strict requirements with respect to the chemical and physical properties of such agents. Therefore, developing rational design methods of synthesis of iron oxide nanoparticles remains of vital importance in nanobiomedicine.Methods: Low toxic superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications in oncology having spherical shape and maghemite structure were produced using the fast microwave synthesis technique and were fully characterized by several complementary methods (transmission electron microscopy [TEM], X-ray diffraction [XRD], dynamic light scattering [DLS], X-ray photoelectron spectroscopy [XPS], X-ray absorption near edge structure [XANES], Mossbauer spectroscopy, and HeLa cells toxicity testing).Results: TEM showed that the majority of the obtained nanoparticles were almost spherical and did not exceed 20 nm in diameter. The averaged DLS hydrodynamic size was found to be ~33 nm, while that of nanocrystallites estimated by XRD was ~16 nm. Both XRD and XPS studies evidenced the maghemite (γ-Fe2O3) atomic and electronic structure of the synthesized nanoparticles. The XANES data analysis demonstrated the structure of the nanoparticles being similar to that of macroscopic maghemite. The Mossbauer spectroscopy revealed the γ-Fe2O3 phase of the nanoparticles and vibration magnetometry study showed that reactive oxygen species in HeLa cells are generated both in the cytoplasm and the nucleus.Conclusion: Quasispherical Fe3+ SPIONs having the maghemite structure with the average size of 16 nm obtained by using the fast microwave synthesis technique are expected to be of great value for theranostic applications in oncology and multimodal anticancer therapy. Keywords: magnetic nanoparticles, SPIONs, maghemite, theranostics in oncology, toxicity, ROS
format	article
author	Kuchma EA Zolotukhin PV Belanova AA Soldatov MA Lastovina TA Kubrin SP Nikolsky AV Mirmikova LI Soldatov AV
author_facet	Kuchma EA Zolotukhin PV Belanova AA Soldatov MA Lastovina TA Kubrin SP Nikolsky AV Mirmikova LI Soldatov AV
author_sort	Kuchma EA
title	Low toxic maghemite nanoparticles for theranostic applications
title_short	Low toxic maghemite nanoparticles for theranostic applications
title_full	Low toxic maghemite nanoparticles for theranostic applications
title_fullStr	Low toxic maghemite nanoparticles for theranostic applications
title_full_unstemmed	Low toxic maghemite nanoparticles for theranostic applications
title_sort	low toxic maghemite nanoparticles for theranostic applications
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/57906359fc5542bcaa69ab4641a21fe4
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Low toxic maghemite nanoparticles for theranostic applications

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