Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

Early life stress has been associated with the occurrence of gastrointestinal diseases later in life, but underlying mechanisms remain poorly understood. Here, Wong et al. show that early life stress leads to expansion of intestinal stem cells and their differentiation into serotonin-producing enter...

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Autores principales:	Hoi Leong Xavier Wong, Hong-yan Qin, Siu Wai Tsang, Xiao Zuo, Sijia Che, Chi Fung Willis Chow, Xi Li, Hai-tao Xiao, Ling Zhao, Tao Huang, Cheng Yuan Lin, Hiu Yee Kwan, Tao Yang, Frank M. Longo, Aiping Lyu, Zhao-xiang Bian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/579ac4bf421f4bc582e3d555badaab42
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spelling	oai:doaj.org-article:579ac4bf421f4bc582e3d555badaab422021-12-02T17:01:26ZEarly life stress disrupts intestinal homeostasis via NGF-TrkA signaling10.1038/s41467-019-09744-32041-1723https://doaj.org/article/579ac4bf421f4bc582e3d555badaab422019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09744-3https://doaj.org/toc/2041-1723Early life stress has been associated with the occurrence of gastrointestinal diseases later in life, but underlying mechanisms remain poorly understood. Here, Wong et al. show that early life stress leads to expansion of intestinal stem cells and their differentiation into serotonin-producing enterochromaffin cells through crosstalk between NGF and Wnt signalling pathways.Hoi Leong Xavier WongHong-yan QinSiu Wai TsangXiao ZuoSijia CheChi Fung Willis ChowXi LiHai-tao XiaoLing ZhaoTao HuangCheng Yuan LinHiu Yee KwanTao YangFrank M. LongoAiping LyuZhao-xiang BianNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hoi Leong Xavier Wong Hong-yan Qin Siu Wai Tsang Xiao Zuo Sijia Che Chi Fung Willis Chow Xi Li Hai-tao Xiao Ling Zhao Tao Huang Cheng Yuan Lin Hiu Yee Kwan Tao Yang Frank M. Longo Aiping Lyu Zhao-xiang Bian Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
description	Early life stress has been associated with the occurrence of gastrointestinal diseases later in life, but underlying mechanisms remain poorly understood. Here, Wong et al. show that early life stress leads to expansion of intestinal stem cells and their differentiation into serotonin-producing enterochromaffin cells through crosstalk between NGF and Wnt signalling pathways.
format	article
author	Hoi Leong Xavier Wong Hong-yan Qin Siu Wai Tsang Xiao Zuo Sijia Che Chi Fung Willis Chow Xi Li Hai-tao Xiao Ling Zhao Tao Huang Cheng Yuan Lin Hiu Yee Kwan Tao Yang Frank M. Longo Aiping Lyu Zhao-xiang Bian
author_facet	Hoi Leong Xavier Wong Hong-yan Qin Siu Wai Tsang Xiao Zuo Sijia Che Chi Fung Willis Chow Xi Li Hai-tao Xiao Ling Zhao Tao Huang Cheng Yuan Lin Hiu Yee Kwan Tao Yang Frank M. Longo Aiping Lyu Zhao-xiang Bian
author_sort	Hoi Leong Xavier Wong
title	Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
title_short	Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
title_full	Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
title_fullStr	Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
title_full_unstemmed	Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
title_sort	early life stress disrupts intestinal homeostasis via ngf-trka signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/579ac4bf421f4bc582e3d555badaab42
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Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

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