Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure

Methamphetamine (METH), the most widely used psychostimulant in Thailand, has been reported to have harmful effects on testicular functions and sperm quality, but its mechanisms are still unclear. Since follicle‒stimulating hormone (FSH) and luteinizing hormone (LH) play important roles in spermat...

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Autores principales:	Paweena Kaewman, Sutisa Nudmamud-Thanoi, Samur Thanoi
Formato:	article
Lenguaje:	EN
Publicado:	Prince of Songkla University 2021
Materias:	fsh receptor lh receptor methamphetamine testis Technology T Technology (General) T1-995 Science Q Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/579d95538f6a451189813963ccc84b16
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spelling	oai:doaj.org-article:579d95538f6a451189813963ccc84b162021-11-07T16:28:04ZChanges of FSH and LH receptors expressions in rat testis after methamphetamine exposure10.14456/sjst-psu.2021.1340125-3395https://doaj.org/article/579d95538f6a451189813963ccc84b162021-08-01T00:00:00Zhttps://rdo.psu.ac.th/sjstweb/journal/43-4/14.pdfhttps://doaj.org/toc/0125-3395Methamphetamine (METH), the most widely used psychostimulant in Thailand, has been reported to have harmful effects on testicular functions and sperm quality, but its mechanisms are still unclear. Since follicle‒stimulating hormone (FSH) and luteinizing hormone (LH) play important roles in spermatogenesis through their receptors in testis, we therefore focused on the changes in FSH and LH receptors after METH administration. Male Sprague–Dawley rats were divided into control and METH‒administrated groups. The mRNA and protein expressions were measured using quantitative RT‒PCR, and immunohistochemistry. The results showed that the rats in AB METH and ED‒binge METH groups had significantly lower the FSH receptor protein expression (strong expression in the stages XII, XIII, XIV, and I of the spermatogenic cycle) compared with the control group but had no significant difference in the mRNA expression of FSH and LH receptors. These results may reflect the adverse effects of METH on FSH functions in testis.Paweena KaewmanSutisa Nudmamud-ThanoiSamur ThanoiPrince of Songkla Universityarticlefsh receptorlh receptormethamphetaminetestisTechnologyTTechnology (General)T1-995ScienceQScience (General)Q1-390ENSongklanakarin Journal of Science and Technology (SJST), Vol 43, Iss 4, Pp 1018-1021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fsh receptor lh receptor methamphetamine testis Technology T Technology (General) T1-995 Science Q Science (General) Q1-390
spellingShingle	fsh receptor lh receptor methamphetamine testis Technology T Technology (General) T1-995 Science Q Science (General) Q1-390 Paweena Kaewman Sutisa Nudmamud-Thanoi Samur Thanoi Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure
description	Methamphetamine (METH), the most widely used psychostimulant in Thailand, has been reported to have harmful effects on testicular functions and sperm quality, but its mechanisms are still unclear. Since follicle‒stimulating hormone (FSH) and luteinizing hormone (LH) play important roles in spermatogenesis through their receptors in testis, we therefore focused on the changes in FSH and LH receptors after METH administration. Male Sprague–Dawley rats were divided into control and METH‒administrated groups. The mRNA and protein expressions were measured using quantitative RT‒PCR, and immunohistochemistry. The results showed that the rats in AB METH and ED‒binge METH groups had significantly lower the FSH receptor protein expression (strong expression in the stages XII, XIII, XIV, and I of the spermatogenic cycle) compared with the control group but had no significant difference in the mRNA expression of FSH and LH receptors. These results may reflect the adverse effects of METH on FSH functions in testis.
format	article
author	Paweena Kaewman Sutisa Nudmamud-Thanoi Samur Thanoi
author_facet	Paweena Kaewman Sutisa Nudmamud-Thanoi Samur Thanoi
author_sort	Paweena Kaewman
title	Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure
title_short	Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure
title_full	Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure
title_fullStr	Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure
title_full_unstemmed	Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure
title_sort	changes of fsh and lh receptors expressions in rat testis after methamphetamine exposure
publisher	Prince of Songkla University
publishDate	2021
url	https://doaj.org/article/579d95538f6a451189813963ccc84b16
work_keys_str_mv	AT paweenakaewman changesoffshandlhreceptorsexpressionsinrattestisaftermethamphetamineexposure AT sutisanudmamudthanoi changesoffshandlhreceptorsexpressionsinrattestisaftermethamphetamineexposure AT samurthanoi changesoffshandlhreceptorsexpressionsinrattestisaftermethamphetamineexposure
_version_	1718443284411449344

Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure

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