Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2

Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2

Dengue virus (DENV) promotes leukocyte-platelet interactions that contribute to pathogenesis. Here, the authors report a role for C-type lectins CLEC2 and CLEC5A in platelet activation and NET formation and show that blockade of CLEC5A and TLR2 attenuates inflammation and increases survival of infec...

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Autores principales: Pei-Shan Sung, Tur-Fu Huang, Shie-Liang Hsieh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/579f44a3873244e7ae349160c67dd772
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spelling oai:doaj.org-article:579f44a3873244e7ae349160c67dd7722021-12-02T15:35:28ZExtracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR210.1038/s41467-019-10360-42041-1723https://doaj.org/article/579f44a3873244e7ae349160c67dd7722019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10360-4https://doaj.org/toc/2041-1723Dengue virus (DENV) promotes leukocyte-platelet interactions that contribute to pathogenesis. Here, the authors report a role for C-type lectins CLEC2 and CLEC5A in platelet activation and NET formation and show that blockade of CLEC5A and TLR2 attenuates inflammation and increases survival of infected mice.Pei-Shan SungTur-Fu HuangShie-Liang HsiehNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pei-Shan Sung
Tur-Fu Huang
Shie-Liang Hsieh
Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
description Dengue virus (DENV) promotes leukocyte-platelet interactions that contribute to pathogenesis. Here, the authors report a role for C-type lectins CLEC2 and CLEC5A in platelet activation and NET formation and show that blockade of CLEC5A and TLR2 attenuates inflammation and increases survival of infected mice.
format article
author Pei-Shan Sung
Tur-Fu Huang
Shie-Liang Hsieh
author_facet Pei-Shan Sung
Tur-Fu Huang
Shie-Liang Hsieh
author_sort Pei-Shan Sung
title Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
title_short Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
title_full Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
title_fullStr Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
title_full_unstemmed Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
title_sort extracellular vesicles from clec2-activated platelets enhance dengue virus-induced lethality via clec5a/tlr2
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/579f44a3873244e7ae349160c67dd772
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AT turfuhuang extracellularvesiclesfromclec2activatedplateletsenhancedenguevirusinducedlethalityviaclec5atlr2
AT shielianghsieh extracellularvesiclesfromclec2activatedplateletsenhancedenguevirusinducedlethalityviaclec5atlr2
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