Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady state, help promote ILC2 activation and type 2...

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Autores principales:	Chizuko Miyamoto, Satoshi Kojo, Motoi Yamashita, Kazuyo Moro, Georges Lacaud, Katsuyuki Shiroguchi, Ichiro Taniuchi, Takashi Ebihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57a0fb2492674412976b7549e953c0c3
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spelling	oai:doaj.org-article:57a0fb2492674412976b7549e953c0c32021-12-02T15:35:57ZRunx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation10.1038/s41467-019-08365-02041-1723https://doaj.org/article/57a0fb2492674412976b7549e953c0c32019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08365-0https://doaj.org/toc/2041-1723Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady state, help promote ILC2 activation and type 2 cytokine production in lung allergy mouse models.Chizuko MiyamotoSatoshi KojoMotoi YamashitaKazuyo MoroGeorges LacaudKatsuyuki ShiroguchiIchiro TaniuchiTakashi EbiharaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chizuko Miyamoto Satoshi Kojo Motoi Yamashita Kazuyo Moro Georges Lacaud Katsuyuki Shiroguchi Ichiro Taniuchi Takashi Ebihara Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation
description	Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady state, help promote ILC2 activation and type 2 cytokine production in lung allergy mouse models.
format	article
author	Chizuko Miyamoto Satoshi Kojo Motoi Yamashita Kazuyo Moro Georges Lacaud Katsuyuki Shiroguchi Ichiro Taniuchi Takashi Ebihara
author_facet	Chizuko Miyamoto Satoshi Kojo Motoi Yamashita Kazuyo Moro Georges Lacaud Katsuyuki Shiroguchi Ichiro Taniuchi Takashi Ebihara
author_sort	Chizuko Miyamoto
title	Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation
title_short	Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation
title_full	Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation
title_fullStr	Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation
title_full_unstemmed	Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation
title_sort	runx/cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/57a0fb2492674412976b7549e953c0c3
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Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

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