Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature

George Kyrgias1,2, Kiki Theodorou3,4, Anna Zygogianni1, Konstantinos Tsanadis2, Stefanos Zervoudis5, John Tzitzikas6, Michael Koukourakis71Academic Radiotherapy, University of Thessaly, Medical School, Greece; 2Radiation Oncology Department, University Hospital of Larissa, Greece; 3Academic Medical...

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Autores principales:	Kyrgias G, Theodorou K, Zygogianni A, Tsanadis K, Zervoudis S, Tzitzikas, Koukourakis M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/57a21bebfcbd4690a874afa6e7ec1790
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spelling	oai:doaj.org-article:57a21bebfcbd4690a874afa6e7ec17902021-12-02T08:17:44ZRadiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature1179-1314https://doaj.org/article/57a21bebfcbd4690a874afa6e7ec17902012-01-01T00:00:00Zhttp://www.dovepress.com/radiotherapy-of-early-breast-cancer-in-scleroderma-patients-our-experi-a9117https://doaj.org/toc/1179-1314George Kyrgias1,2, Kiki Theodorou3,4, Anna Zygogianni1, Konstantinos Tsanadis2, Stefanos Zervoudis5, John Tzitzikas6, Michael Koukourakis71Academic Radiotherapy, University of Thessaly, Medical School, Greece; 2Radiation Oncology Department, University Hospital of Larissa, Greece; 3Academic Medical Physics, University of Thessaly, Medical School, Greece; 4Medical Physics Department, University Hospital of Larissa, 5Breast Unit, REA Hospital, Athens, Greece; 6Radiation Oncology Department, AHEPA University Hospital of Thessaloniki, Greece; 7Radiotherapy-Oncology Department, University Hospital of Alexandroupolis, GreecePurpose: Connective vascular diseases (CVD), including scleroderma, are reported to represent for some researchers a relative contraindication and for others absolute contraindication for radiotherapy. The purpose of our study is to add four new cases to the existing body of international literature and to determine whether women with pre-existing scleroderma who have been surgically treated for early breast cancer could undergo postsurgical radiotherapy without serious early and late complications.Patients and methods: From May 1998 to November 2010, we irradiated for early breast cancer four patients suffering from pre-existing scleroderma; after conservative surgery, we performed whole breast postoperative radiotherapy of 50.4 Gy total dose to the whole breast plus a 9 Gy boost to the tumor bed. We reviewed the records of all four patients and evaluated the early and late reactions using acute radiation morbidity scoring criteria (Radiation Therapy Oncology Group [RTOG], American College of Radiology, Philadelphia, PA) and late radiation morbidity scoring scheme (European Organisation for Research and Treatment of Cancer [EORTC], Brussels, Belgium and RTOG).Results: After a median follow-up of 105 months (range 12&ndash;155 months) the early and late toxicity concerning the skin, the subcutaneous tissues, the lungs, and the heart have been acceptable and are in full accordance with what have been reported in international literature.Conclusion: This study matches global experience, which shows that patients with scleroderma and breast cancer must be discussed by the multidisciplinary tumor board in order for a personalized treatment strategy to be formulated. Radiation therapy can be proposed as a postsurgical therapeutic option in selected cases.Keywords: breast radiotherapy, early toxicity, late complications, short review, sclerodermaKyrgias GTheodorou KZygogianni ATsanadis KZervoudis STzitzikasKoukourakis MDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2012, Iss default, Pp 3-8 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kyrgias G Theodorou K Zygogianni A Tsanadis K Zervoudis S Tzitzikas Koukourakis M Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature
description	George Kyrgias1,2, Kiki Theodorou3,4, Anna Zygogianni1, Konstantinos Tsanadis2, Stefanos Zervoudis5, John Tzitzikas6, Michael Koukourakis71Academic Radiotherapy, University of Thessaly, Medical School, Greece; 2Radiation Oncology Department, University Hospital of Larissa, Greece; 3Academic Medical Physics, University of Thessaly, Medical School, Greece; 4Medical Physics Department, University Hospital of Larissa, 5Breast Unit, REA Hospital, Athens, Greece; 6Radiation Oncology Department, AHEPA University Hospital of Thessaloniki, Greece; 7Radiotherapy-Oncology Department, University Hospital of Alexandroupolis, GreecePurpose: Connective vascular diseases (CVD), including scleroderma, are reported to represent for some researchers a relative contraindication and for others absolute contraindication for radiotherapy. The purpose of our study is to add four new cases to the existing body of international literature and to determine whether women with pre-existing scleroderma who have been surgically treated for early breast cancer could undergo postsurgical radiotherapy without serious early and late complications.Patients and methods: From May 1998 to November 2010, we irradiated for early breast cancer four patients suffering from pre-existing scleroderma; after conservative surgery, we performed whole breast postoperative radiotherapy of 50.4 Gy total dose to the whole breast plus a 9 Gy boost to the tumor bed. We reviewed the records of all four patients and evaluated the early and late reactions using acute radiation morbidity scoring criteria (Radiation Therapy Oncology Group [RTOG], American College of Radiology, Philadelphia, PA) and late radiation morbidity scoring scheme (European Organisation for Research and Treatment of Cancer [EORTC], Brussels, Belgium and RTOG).Results: After a median follow-up of 105 months (range 12&ndash;155 months) the early and late toxicity concerning the skin, the subcutaneous tissues, the lungs, and the heart have been acceptable and are in full accordance with what have been reported in international literature.Conclusion: This study matches global experience, which shows that patients with scleroderma and breast cancer must be discussed by the multidisciplinary tumor board in order for a personalized treatment strategy to be formulated. Radiation therapy can be proposed as a postsurgical therapeutic option in selected cases.Keywords: breast radiotherapy, early toxicity, late complications, short review, scleroderma
format	article
author	Kyrgias G Theodorou K Zygogianni A Tsanadis K Zervoudis S Tzitzikas Koukourakis M
author_facet	Kyrgias G Theodorou K Zygogianni A Tsanadis K Zervoudis S Tzitzikas Koukourakis M
author_sort	Kyrgias G
title	Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature
title_short	Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature
title_full	Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature
title_fullStr	Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature
title_full_unstemmed	Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature
title_sort	radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/57a21bebfcbd4690a874afa6e7ec1790
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Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature

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