Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal, the binding site of CRM1, with advanced supramo...

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Autores principales:	Annika Meiners, Sandra Bäcker, Inesa Hadrović, Christian Heid, Christine Beuck, Yasser B. Ruiz-Blanco, Joel Mieres-Perez, Marius Pörschke, Jean-Noël Grad, Cecilia Vallet, Daniel Hoffmann, Peter Bayer, Elsa Sánchez-García, Thomas Schrader, Shirley K. Knauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57a8962dc1a04df6ae79162b6fd9c226
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spelling	oai:doaj.org-article:57a8962dc1a04df6ae79162b6fd9c2262021-12-02T13:33:04ZSpecific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers10.1038/s41467-021-21753-92041-1723https://doaj.org/article/57a8962dc1a04df6ae79162b6fd9c2262021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21753-9https://doaj.org/toc/2041-1723Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal, the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine.Annika MeinersSandra BäckerInesa HadrovićChristian HeidChristine BeuckYasser B. Ruiz-BlancoJoel Mieres-PerezMarius PörschkeJean-Noël GradCecilia ValletDaniel HoffmannPeter BayerElsa Sánchez-GarcíaThomas SchraderShirley K. KnauerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annika Meiners Sandra Bäcker Inesa Hadrović Christian Heid Christine Beuck Yasser B. Ruiz-Blanco Joel Mieres-Perez Marius Pörschke Jean-Noël Grad Cecilia Vallet Daniel Hoffmann Peter Bayer Elsa Sánchez-García Thomas Schrader Shirley K. Knauer Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
description	Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal, the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine.
format	article
author	Annika Meiners Sandra Bäcker Inesa Hadrović Christian Heid Christine Beuck Yasser B. Ruiz-Blanco Joel Mieres-Perez Marius Pörschke Jean-Noël Grad Cecilia Vallet Daniel Hoffmann Peter Bayer Elsa Sánchez-García Thomas Schrader Shirley K. Knauer
author_facet	Annika Meiners Sandra Bäcker Inesa Hadrović Christian Heid Christine Beuck Yasser B. Ruiz-Blanco Joel Mieres-Perez Marius Pörschke Jean-Noël Grad Cecilia Vallet Daniel Hoffmann Peter Bayer Elsa Sánchez-García Thomas Schrader Shirley K. Knauer
author_sort	Annika Meiners
title	Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
title_short	Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
title_full	Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
title_fullStr	Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
title_full_unstemmed	Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
title_sort	specific inhibition of the survivin–crm1 interaction by peptide-modified molecular tweezers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57a8962dc1a04df6ae79162b6fd9c226
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Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

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