Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study

Abstract We aimed to explore the clinicopathological features and survival-related factors for intrahepatic cholangiocarcinoma (ICC). Eligible data were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2015. Totally, 4595 ICC patients were collected with a m...

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Autores principales:	Tian-hua Yu, Xin Chen, Xuan-he Zhang, Er-chi Zhang, Cai-xia Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57a9bf9bab13432e8137b13e13b4103a
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spelling	oai:doaj.org-article:57a9bf9bab13432e8137b13e13b4103a2021-12-02T14:03:58ZClinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study10.1038/s41598-021-83149-52045-2322https://doaj.org/article/57a9bf9bab13432e8137b13e13b4103a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83149-5https://doaj.org/toc/2045-2322Abstract We aimed to explore the clinicopathological features and survival-related factors for intrahepatic cholangiocarcinoma (ICC). Eligible data were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2015. Totally, 4595 ICC patients were collected with a male to female ratio of nearly 1:1. The higher proportion of ICC patients was elderly, tumor size ≥ 5 cm and advanced AJCC stage. Most patients (79.2%) have no surgery, while low proportion of patients receiving radiotherapy (15.1%). The median survival was 7.0 months (range 0–153 months). The 5-year CSS and OS rates were 8.96% and 7.90%. Multivariate analysis found that elderly age (aged ≥ 65 years old), male, diagnosis at 2008–2011, higher grade, tumor size ≥ 5 cm, and advanced AJCC stage were independent factors for poorer prognosis; while API/AI (American Indian/AK Native, Asian/Pacific Islander) race, married, chemotherapy, surgery and radiotherapy were independent favorable factors in both CSS and OS. Furthermore, stratified analysis found that chemotherapy and radiotherapy improved CSS and OS in patients without surgery. Age, sex, race, years of diagnosis, married status, grade, tumor size, AJCC stage, surgery, chemotherapy and radiotherapy were significantly related to prognosis of ICC. Chemotherapy and radiotherapy could significantly improve survival in patients without surgery.Tian-hua YuXin ChenXuan-he ZhangEr-chi ZhangCai-xia SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tian-hua Yu Xin Chen Xuan-he Zhang Er-chi Zhang Cai-xia Sun Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study
description	Abstract We aimed to explore the clinicopathological features and survival-related factors for intrahepatic cholangiocarcinoma (ICC). Eligible data were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2015. Totally, 4595 ICC patients were collected with a male to female ratio of nearly 1:1. The higher proportion of ICC patients was elderly, tumor size ≥ 5 cm and advanced AJCC stage. Most patients (79.2%) have no surgery, while low proportion of patients receiving radiotherapy (15.1%). The median survival was 7.0 months (range 0–153 months). The 5-year CSS and OS rates were 8.96% and 7.90%. Multivariate analysis found that elderly age (aged ≥ 65 years old), male, diagnosis at 2008–2011, higher grade, tumor size ≥ 5 cm, and advanced AJCC stage were independent factors for poorer prognosis; while API/AI (American Indian/AK Native, Asian/Pacific Islander) race, married, chemotherapy, surgery and radiotherapy were independent favorable factors in both CSS and OS. Furthermore, stratified analysis found that chemotherapy and radiotherapy improved CSS and OS in patients without surgery. Age, sex, race, years of diagnosis, married status, grade, tumor size, AJCC stage, surgery, chemotherapy and radiotherapy were significantly related to prognosis of ICC. Chemotherapy and radiotherapy could significantly improve survival in patients without surgery.
format	article
author	Tian-hua Yu Xin Chen Xuan-he Zhang Er-chi Zhang Cai-xia Sun
author_facet	Tian-hua Yu Xin Chen Xuan-he Zhang Er-chi Zhang Cai-xia Sun
author_sort	Tian-hua Yu
title	Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study
title_short	Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study
title_full	Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study
title_fullStr	Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study
title_full_unstemmed	Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study
title_sort	clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57a9bf9bab13432e8137b13e13b4103a
work_keys_str_mv	AT tianhuayu clinicopathologicalcharacteristicsandprognosticfactorsforintrahepaticcholangiocarcinomaapopulationbasedstudy AT xinchen clinicopathologicalcharacteristicsandprognosticfactorsforintrahepaticcholangiocarcinomaapopulationbasedstudy AT xuanhezhang clinicopathologicalcharacteristicsandprognosticfactorsforintrahepaticcholangiocarcinomaapopulationbasedstudy AT erchizhang clinicopathologicalcharacteristicsandprognosticfactorsforintrahepaticcholangiocarcinomaapopulationbasedstudy AT caixiasun clinicopathologicalcharacteristicsandprognosticfactorsforintrahepaticcholangiocarcinomaapopulationbasedstudy
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Clinicopathological characteristics and prognostic factors for intrahepatic cholangiocarcinoma: a population-based study

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