Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy

Qing Zhou, Xiaoli Liu, Hexuan Zhang, Zhigang Zhao, Qiang Li, Hongbo He, Zhiming Zhu, Zhencheng Yan Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital and the Research Institute of Surgery, Army Medical Un...

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Autores principales:	Zhou Q, Liu X, Zhang H, Zhao Z, Li Q, He H, Zhu Z, Yan Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	adrenal cortisol adenoma adrenal artery ablation adrenal venous sampling cushing’s syndrome Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/57ae29b71c364cf986ee200e1481254c
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spelling	oai:doaj.org-article:57ae29b71c364cf986ee200e1481254c2021-12-02T13:13:52ZAdrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy1178-7007https://doaj.org/article/57ae29b71c364cf986ee200e1481254c2020-10-01T00:00:00Zhttps://www.dovepress.com/adrenal-artery-ablation-for-the-treatment-of-hypercortisolism-based-on-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Qing Zhou, Xiaoli Liu, Hexuan Zhang, Zhigang Zhao, Qiang Li, Hongbo He, Zhiming Zhu, Zhencheng Yan Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital and the Research Institute of Surgery, Army Medical University, Chongqing 400042, People’s Republic of ChinaCorrespondence: Zhencheng YanDepartment of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital and the Research Institute of Surgery, Army Medical University, Chongqing 400042, People’s Republic of ChinaTel +86-23-68757883Email zhenchengyan@sina.comAim: Hypercortisolism is characterized by metabolic disorders and high mortality rates. Adrenalectomy and medical therapies are considered major treatment options. However, some patients, especially young patients, are strongly against undergoing surgery in case of secondary hypocortisolism or relapses that require replacement supplements or pharmacological interventions. In such cases, alternative therapies are needed to treat hypercortisolism.Methods: We report a 27-year-old Chinese female with adrenal cortisol-producing adenoma. The patient’s circadian rhythm and concentrations of cortisol were abnormal, accompanying with an increased 24-hour urinary cortisol level. Computed tomography (CT) revealed a nodular soft-tissue mass in the right adrenal gland.Results: Cortisol hypersecretion from the right adrenal gland was verified by adrenal venous sampling (AVS). Adrenal artery ablation was performed. After ablation, long-term follow-up showed that the patient’s symptoms subsided and abnormal laboratory test results returned to normal without pharmacological treatment.Conclusion: AVS might be a promising method to aid the diagnosis of cortisol-producing adenoma. Adrenal artery ablation is minimally invasive and may be useful for the treatment of adrenal adenoma or nodular diseases, especially in patients who cannot undergo surgery.Keywords: adrenal cortisol adenoma, adrenal artery ablation, adrenal venous sampling, Cushing’s syndromeZhou QLiu XZhang HZhao ZLi QHe HZhu ZYan ZDove Medical Pressarticleadrenal cortisol adenomaadrenal artery ablationadrenal venous samplingcushing’s syndromeSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3519-3525 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	adrenal cortisol adenoma adrenal artery ablation adrenal venous sampling cushing’s syndrome Specialties of internal medicine RC581-951
spellingShingle	adrenal cortisol adenoma adrenal artery ablation adrenal venous sampling cushing’s syndrome Specialties of internal medicine RC581-951 Zhou Q Liu X Zhang H Zhao Z Li Q He H Zhu Z Yan Z Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy
description	Qing Zhou, Xiaoli Liu, Hexuan Zhang, Zhigang Zhao, Qiang Li, Hongbo He, Zhiming Zhu, Zhencheng Yan Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital and the Research Institute of Surgery, Army Medical University, Chongqing 400042, People’s Republic of ChinaCorrespondence: Zhencheng YanDepartment of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital and the Research Institute of Surgery, Army Medical University, Chongqing 400042, People’s Republic of ChinaTel +86-23-68757883Email zhenchengyan@sina.comAim: Hypercortisolism is characterized by metabolic disorders and high mortality rates. Adrenalectomy and medical therapies are considered major treatment options. However, some patients, especially young patients, are strongly against undergoing surgery in case of secondary hypocortisolism or relapses that require replacement supplements or pharmacological interventions. In such cases, alternative therapies are needed to treat hypercortisolism.Methods: We report a 27-year-old Chinese female with adrenal cortisol-producing adenoma. The patient’s circadian rhythm and concentrations of cortisol were abnormal, accompanying with an increased 24-hour urinary cortisol level. Computed tomography (CT) revealed a nodular soft-tissue mass in the right adrenal gland.Results: Cortisol hypersecretion from the right adrenal gland was verified by adrenal venous sampling (AVS). Adrenal artery ablation was performed. After ablation, long-term follow-up showed that the patient’s symptoms subsided and abnormal laboratory test results returned to normal without pharmacological treatment.Conclusion: AVS might be a promising method to aid the diagnosis of cortisol-producing adenoma. Adrenal artery ablation is minimally invasive and may be useful for the treatment of adrenal adenoma or nodular diseases, especially in patients who cannot undergo surgery.Keywords: adrenal cortisol adenoma, adrenal artery ablation, adrenal venous sampling, Cushing’s syndrome
format	article
author	Zhou Q Liu X Zhang H Zhao Z Li Q He H Zhu Z Yan Z
author_facet	Zhou Q Liu X Zhang H Zhao Z Li Q He H Zhu Z Yan Z
author_sort	Zhou Q
title	Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy
title_short	Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy
title_full	Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy
title_fullStr	Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy
title_full_unstemmed	Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy
title_sort	adrenal artery ablation for the treatment of hypercortisolism based on adrenal venous sampling: a potential therapeutic strategy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/57ae29b71c364cf986ee200e1481254c
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Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy

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